Prevalence of HypoSpadias in GrandSons of Women exposed to DiEthylStilbestrol during Pregnancy

Significant proportion of boys exhibiting hypospadias in DES GrandSons

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Significant proportion of boys exhibiting hypospadias in DES GrandSons.
Hhorages 2011 study.

Prenatal Diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males.

This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.

Read full study: Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study
NCBI, by Marie-Odile Soyer-Gobillard, 30 June 2011.

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