Testosterone use in the United States tripled from 2001 through 2011, mostly in men without a clear indication.
In late 2013 and early 2014, two studies reported increased myocardial infarction and stroke associated with testosterone use.
The US Food and Drug Administration (FDA) issued a safety bulletin on January 31, 2014.
After a decade of growth, the percentage of US men receiving testosterone prescriptions decreased from 2013, falling to less than 2% of men by 2016.
This prescribing trends study was published July 10, 2018.