More treatment cycles than ever before; success rates remain constant
Multiple birth rate falls again
Number of women over 45 using donor eggs outnumbers those using their own
Number of IVF cycles using donated eggs and donated sperm more than doubles in five years
Number of same-sex female couples receiving treatment increases
New figures on fertility treatment released today by the Human Fertilisation and Embryology Authority (HFEA) reveal a continuing rise in the overall number of IVF cycles in the UK, with more undertaken in 2013 than ever before.
The report, “Fertility treatment 2013: trends and figures“, contains key statistics on fertility trends in the UK. It covers treatment cycles and outcomes for treatments started in 2012 and 2013 and how these coincide with short and long term trends. It is the fourth of its kind to be published by the HFEA.
In 2013, 49,636 women had a total of 64,600 cycles of IVF and 2,379 women had a total of 4,611 cycles of donor insemination (DI), representing an increase in both categories from the previous year. Overall, success rates have remained constant at around 25%.
Women over 40 represent the minority of all patients treated, with women aged over 45 accounting for just 2.% of all treatments. More than two-thirds of women undergoing treatment are aged 37 and under, while the average age for treatment remains static at 35. The report also shows that a majority of women over 45 are using donor eggs rather than their own when trying to conceive.
The number of IVF treatment cycles involving same-sex female couples has increased by nearly 20% year-on-year, rising from 766 treatments in 2011 to 902 in 2012. The number of donor insemination cycles involving same-sex couples (DI) rose by nearly 15%, from 1,271 in 2011 to 1,458 in 2012. These amount to a minority of overall treatments undertaken in the period covered.
Elsewhere, the HFEA’s “One at a Time” campaign to reduce multiple births is shown to have had good impact, with multiple births continuing to decrease. The report shows that multiple births occurred in 16.9% of treatment cycles in 2012, down from 18.8% in 2011.
The report also shows that the number of IVF treatment cycles using both donor eggs and donor sperm has doubled over the last five years, while the use of frozen embryos is now involved in more than 20% of all treatments.
Sally Cheshire, Chair of the HFEA welcomed the publication of the report:
“At the HFEA we are committed to ensuring high quality care for everyone affected by assisted reproduction, and this report is key to that commitment. It offers unrivalled insight into one of the world’s most advanced IVF sectors, helping to inform the decisions of patients and clinicians alike.
We are very pleased to see that outcomes in most categories are improving each year, and are particularly heartened by the continuing downward trend in multiple births, something we’ve worked hard with professionals to achieve.
But as well as providing data, over time these reports offer us a unique insight into the changing nature of social norms, whether that is same-sex parenting or older mums. In that sense they have become a fascinating resource not just for patients and clinicians, but for everyone.”
Other findings include:
Pregnancy rate (per embryo transfer) rises for all age ranges
The live births rate is at highest-ever level
Number of IVF cycles using fresh donated eggs up more than 50% in five years
London and South East account for over a third of all treatments
Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection
” Treating a cancerous tumor is like watering a houseplant with a fire hose – too much water kills the plant, just as too much chemotherapy and radiation kills the patient before it kills the tumor. However, if the patient’s gastrointestinal tract remains healthy and functioning, the patient’s chances of survival increase exponentially… ”
Cancer research has been righteously and successfully focused on prevention, early detection and identification of specific molecular targets that distinguish the malignant cells from the neighboring benign cells1. However, a major clinical challenge concerns how we can reduce lethal tissue injury caused by intensive chemoradiotherapy during treatment of late-staged metastatic cancers. Here we tested whether induction of adult stem cells repairs chemoradiation-induced tissue injury and prolongs overall survival. We found that intestinal stem cells (ISCs)2 expressed Slit2 and its single-span transmembrane cell-surface receptor Roundabout 1 (Robo1)3,4. Partial genetic deletion of Robo1 decreased intestinal stem cells (ISCs) and caused villus hypotrophy, whereas Slit2 transgene increased ISCs and triggered villus hypertrophy. During lethal dosages of chemoradiation, administering a short pulse of R-spondin 1 (Rspo1; a Wnt agonist)5–14 plus Slit2 reduced ISC loss, mitigated gut impairment and protected animals from death, without concomitantly decreasing tumor sensitivity to chemotherapy. Rspo1 and Slit2 may thus act as therapeutic adjuvants to enhance host tolerance to aggressive chemoradiotherapy for eradicating metastatic cancers.
Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection, NCBI, PMCID: PMC3888063, NIHMSID: NIHMS498272, Jul 31, 2013. doi: 10.1038/nature12416
Cancer breakthrough: Probiotics may save patients from deadly chemotherapy; antibiotics may cause chemo to be fatal, NaturalNews, 041449, August 01, 2013
Gut reaction: Mice survive lethal doses of chemotherapy, MichiganNews, 21613, Jul 31, 2013