Use prescription painkillers only as directed by a health care provider Get help for substance abuse problems if needed (1-800-662-HELP)
Prescription Painkiller Overdoses, A growing epidemic, especially among women
About 18 women die every day of a prescription painkiller overdose in the US, more than 6,600 deaths in 2010. Prescription painkiller overdoses – opioid or narcotic pain relievers, including drugs such as Vicodin (hydrocodone), OxyContin (oxycodone), Opana (oxymorphone), and methadone – are an under-recognized and growing problem for women.
Although men are still more likely to die of prescription painkiller overdoses (more than 10,000 deaths in 2010), the gap between men and women is closing. Deaths from prescription painkiller overdose among women have risen more sharply than among men; since 1999 the percentage increase in deaths was more than 400% among women compared to 265% in men. This rise relates closely to increased prescribing of these drugs during the past decade. Health care providers can help improve the way painkillers are prescribed while making sure women have access to safe, effective pain treatment.
Diethylstilboestrol is a synthetic estrogen associated with adverse effects on reproductive organs
2013 Study Abstract
BACKGROUND: Diethylstilboestrol (DES) is a synthetic estrogen associated with adverse effects on reproductive organs. DES-induced toxicity of the mouse seminal vesicle (SV) is mediated by estrogen receptor α (ERα), which alters expression of seminal vesicle secretory protein IV (Svs4) and lactoferrin (Ltf) genes.
OBJECTIVES: We examined a role for nuclear receptor activity in association with DNA methylation and altered gene expression.
METHODS: We used the neonatal DES exposure mouse model to examine DNA methylation patterns via bisulfite conversion sequencing in SVs of wild-type (WT) and ERα-knockout (αERKO) mice.
RESULTS: The DNA methylation status at four specific CpGs (-160, -237, -306, and -367) in the Svs4 gene promoter changed during mouse development from methylated to unmethylated, and DES prevented this change at 10 weeks of age in WT SV. At two specific CpGs (-449 and -459) of the Ltf gene promoter, DES altered the methylation status from methylated to unmethylated. Alterations in DNA methylation of Svs4 and Ltf were not observed in αERKO SVs, suggesting that changes of methylation status at these CpGs are ERα dependent. The methylation status was associated with the level of gene expression. In addition, gene expression of three epigenetic modifiers-DNMT3A, MBD2, and HDAC2-increased in the SV of DES-exposed WT mice.
CONCLUSION: DES-induced hormonal toxicity resulted from altered gene expression of Svs4 and Ltf associated with changes in DNA methylation that were mediated by ERα. Alterations in gene expression of DNMT3A, MBD2, and HDAC2 in DES-exposed male mice may be involved in mediating the changes in methylation status in the SV.
CITATION: Li Y, Hamilton KJ, Lai AY, Burns KA, Li L, Wade PA, Korach KS. 2014. Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle.
Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle, NCBI, PMD: 24316720, 2014 Mar;122(3):262-8. doi: 10.1289/ehp.1307351. Epub 2013 Dec 5.
Full Text EHP1307351 Environ Health Perspect; DOI:10.1289/ehp.1307351
The Centers for Disease Control and Prevention’s National Center for Health Statistics 2013 report includes a special section on prescription drugs:
About half of all Americans in 2007-2010 reported taking one or more prescription drugs in the past 30 days. Use increased with age; 1 in 4 children took one or more prescription drugs in the past 30 days compared to 9 in 10 adults aged 65 and over.
Cardiovascular agents (used to treat high blood pressure, heart disease or kidney disease) and cholesterol-lowering drugs were two of the most commonly used classes of prescription drugs among adults aged 18-64 years and 65 and over in 2007-2010. Nearly 18 percent (17.7) of adults aged 18-64 took at least one cardiovascular agent in the past 30 days.
The use of cholesterol-lowering drugs among those aged 18-64 has increased more than six-fold since 1988-1994, due in part to the introduction and acceptance of statin drugs to lower cholesterol.
Other commonly used prescription drugs among adults aged 18-64 years were analgesics to relieve pain and antidepressants.
The prescribing of antibiotics during medical visits for cold symptoms declined 39 percent between 1995-1996 and 2009-2010.
Among adults aged 65 and over, 70.2 percent took at least one cardiovascular agent and 46.7 percent took a cholesterol-lowering drug in the past 30 days in 2007-2010. The use of cholesterol-lowering drugs in this age group has increased more than seven-fold since 1988-1994.
Other commonly used prescription drugs among those aged 65 and older included analgesics, blood thinners and diabetes medications.
In 2012, adults aged 18-64 years who were uninsured for all or part of the past year were more than four times as likely to report not getting needed prescription drugs due to cost as adults who were insured for the whole year (22.4 percent compared to 5.0 percent).
The use of antidepressants among adults aged 18 and over increased more than four-fold, from 2.4 percent to 10.8 percent between 1988-1994 and 2007-2010.
Drug poisoning deaths involving opioid analgesics among those aged 15 and over more than tripled in the past decade, from 1.9 deaths per 100,000 population in 1999-2000 to 6.6 in 2009-2010.
Pédiatre, Oncologue, Nicole Delépine dénonce le basculement de notre système de santé
” Alors que la mortalité par cancer ne cessait de diminuer depuis plus de trente ans, le cancer a été déclaré priorité de santé publique dès 1998 et l objet de plans successifs d organisation extrêmement coûteux (1,97 milliard d euros pour le plan 2009-2014). Le coût du cancer s élève environ à 14 milliards d euros annuels pour 350 000 nouveaux patients par an soit 8% des dépenses de santé pour 2% de la population. Les valeurs boursières pharmaceutiques sont devenues valeurs refuges. La mise à disposition très précoce de nouvelles molécules dites innovantes pour 1 milliard d euros annuel échappe au circuit sécurisé habituel du médicament. Vendues à prix d or avant même les résultats des essais thérapeutiques, elles mettent en péril l équilibre de la Sécurité sociale sans bénéfice majeur pour les patients et posent la question du bien-fondé de ces décisions autocratiques au profit de Big Pharma. Et si le système d organisation des soins et de la recherche en cancérologie mis en place depuis 2005 mettait à mal l indépendance professionnelle du médecin, ruinait le colloque singulier médecin/patient, remplaçait la médecine adaptée à chacun par des recettes obligées venues d en haut et appliquées à tous ? La liberté de soigner est essentielle. Sa perte pose non seulement le problème de la qualité des soins mais aussi celui du totalitarisme rampant qui ronge notre société.
Nicole Delépine – auteure de La face cachée des médicaments – dénonce le basculement de notre système de santé dans le capitalisme financier et le despotisme bureaucratique, et explique que la convergence d intérêts politiques et de lobbies médicopharmaceutiques a conduit à une OPA sur le cancer. Dans ce livre de combat, elle appelle solennellement les citoyens à reprendre en mains leur avenir et plus particulièrement dans le domaine de la Santé en luttant avec détermination contre la perversité des conflits d intérêt. ”
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Sources: Amazon.Fr – date de publication: 14 février 2013
While there may be some phone apps you can live without, there are some that can keep you healthy!
When it comes to your phone, do you suffer from app overload? While there may be some phone apps you can live without, there are some that can really help you on your road to staying healthy! Joyce Evans gives us a nice list of things you can use to lose weight, check your pulse, eat right and so much more.
In a world first collaboration lead by Cancer Research UK, Amazon Web Services, Facebook and Google developers joined academics, scientists, gamers and designers for a weekend GameJam. Their aim was to transform Cancer Research UK’s cancer gene data into an engaging and playable game that would generate robust scientific analysis. In just 48 sleep deprived hours, this inspirational collaboration produced 12 gaming prototypes based on Cancer Research UK’s cancer gene data – truly epic achievement.
Play to CureGenes in Space is a pioneering mobile phone game from Cancer Research UK, which lets players unravel real cancer data through a space game. What would have taken scientists hours to analyse, can now be done faster with your help and the collective force of thousands of players. Watch this to find out more about the game and see real game play.
To: Rt Hon Stephen Dorrell MP, Chair of the Health Select Committee
We are appealing to you on behalf of the Fetal Anti Convulsant Trust and all people affected by Fetal AntiConvulsant Syndromes.
Please could you request a public Inquiry as to why Sodium Valproate (Epilim) has been given out for over 30yrs and is still being given out to women with Epilepsy and other conditions like Bi-Polar, manic Depression, Persistant Headaches, and many more, when there is a chance that they may want to start a family. There needs to be more awareness of the fact that research shows conclusively that there is a 12% risk of the child having Neuro Developmental Problems, with the highest incidence being of an Autistic Spectrum Disorder, and that the risk increases to 15% if on a second medication.The risk factor then rises to 40% if you take into account all physical and cognitive impairments also. Some physical impairments are so severe the child doesn’t survive into adulthood.