Pharmaceuticals and personal care products found in the Great Lakes above concentrations of environmental concern
Prescription drugs are contaminating Lake Michigan two miles from Milwaukee’s sewage outfalls, suggesting that the lake is not diluting the compounds as most scientists expected, according to new research. This ability of the drugs to travel and remain at relatively high concentrations means that fish and other aquatic life are exposed, so there could be “some serious near-shore impacts,” said Rebecca Klaper, an associate professor at the University of Wisconsin-Milwaukee. In addition, Milwaukee draws its drinking water from Lake Michigan, although no pharmaceuticals have been detected in the city’s water. The researchers reported that 14 of the chemicals “were found to be of medium or high ecological risk,” and that the concentrations “indicate a significant threat to the health of the Great Lakes” .
Vous êtes nées entre 1950 et 1977 d’une mère qui n’a pas pris de Distilbène? Votre parcours médical sera très utile pour établir si les descendantes des femmes traitées pendant leur grossesse par cette hormone de synthèse ont un risque accru de déclencher un cancer du sein. Des volontaires sont encore nécessaires. Le questionnaire est en ligne jusqu’au 9 septembre.
Model, actress and billboard recording artist Amy Weber opens up about her struggle to become a mother after undergoing treatment for cervical cancer, brought on by a now banned pregnancy drug called DES. In May 2009, Amy was finally able to fulfill her dream of becoming a mother. See what she went through during her high-risk pregnancy, and meet her family!
FACSaware aims to raising global awareness of Fetal Anti Convulsant Syndromes and other teratogen-related issues
FACSaware aims to raising global awareness of Fetal Anti Convulsant Syndromes and other Teratogen related syndromes. The Fetal AntiConvulsant Trust (F.A.C.T.) was set up in 2011 to campaign for responsibility from the government and drug company.
Watch the video from the UK Parlement Private Members Debate Fetal anti-convulsant syndrome with Anas Sarwar
Concern about the possible impact of estrogen-like substances found in the environment on a range of health conditions has spurred research in this area. Diethylstilbestrol (DES) is an example of an endocrine-disruptor i.e., chemicals that interfere with the body’s hormone system. While prenatal exposure to DES is known to increase risks of vaginal or cervical cancer and poor reproductive outcomes in women, and abnormalities in the urinary and genital tracts in men information on non-reproductive medical conditions are lacking.
We studied the associations between prenatal DES exposure and the occurrence of cardiovascular disease, diabetes, osteoporosis and related conditions among 5,590 exposed and unexposed daughters and 2,657 exposed and unexposed sons in the NCI Combined DES Follow-up Study. The associations took into account the participants’ birth year, sex, weight adjusted for height, smoking status, alcohol use, educational status, number of general physical examinations in the past 5 years, and study site.
Comparing participants exposed prenatally to DES with those who were not exposed, there were increases in the risk of developing cardiovascular disease (27%), heart attacks (28%), hypertension (14%), and high cholesterol (12%). In addition, the risks of developing diabetes, coronary artery disease, osteoporosis and fractures were elevated, but these findings were possibly due to chance. The associations of DES and the medical conditions did not differ by dose and timing of DES exposure, nor, in the women, by presence or absence of vaginal epithelial changes (a marker of DES host susceptibility).
This study raises the possibility that prenatal DES exposure is associated with several common medical conditions in adulthood, although there is the possibility that our results are explained by differences in the reporting of conditions by the exposed and unexposed participants, or by other factors related to both the conditions and DES exposure status that were not accounted for in the study, such as dietary intake and physical activity. We plan to continue to study these associations by obtaining medical records to confirm the diagnoses in the current round of the study.
DES Info commented: ” DES Exposure estimated hazard ratios and their associated 95% confidence intervals for the associations between prenatal DES exposure and the occurrence of cardiovascular disease, diabetes, osteoporosis, and related conditions among 5590 female and 2657 male offspring followed from 1994 through 2006, adjusted for birth year, cohort, sex, body mass index, smoking status, alcohol use, education, and number of general physical examinations in the past 5 years “.
2013 Study Abstract:
BACKGROUND: Diethylstilbestrol (DES), a synthetic estrogen that was used in pregnancy, is a prototype endocrine-disrupting chemical. Although prenatal exposure to DES is known to increase risks of vaginal/cervical adenocarcinoma and adverse reproductive outcomes in women, and urogenital anomalies in men, data on nonreproductive medical conditions are lacking.
METHODS: We estimated hazard ratios and their associated 95% confidence intervals for the associations between prenatal DES exposure and the occurrence of cardiovascular disease, diabetes, osteoporosis, and related conditions among 5590 female and 2657 male offspring followed from 1994 through 2006, adjusted for birth year, cohort, sex, body mass index, smoking status, alcohol use, education, and number of general physical examinations in the past 5 years.
RESULTS: Comparing persons exposed prenatally to DES with those who were not exposed, the hazard ratios were 1.21 (95% confidence interval = 0.96-1.54) for diabetes, 1.27 (1.00-1.62) for all cardiovascular disease, 1.18 (0.88-1.59) for coronary artery disease, 1.28 (0.88-1.86) for myocardial infarction, 1.12 (1.02-1.22) for high cholesterol, 1.14 (1.02-1.28) for hypertension, 1.24 (0.99-1.54) for osteoporosis, and 1.30 (0.95-1.79) for fractures. The associations did not differ by dose and timing of DES exposure, nor, in the women, by the presence or absence of vaginal epithelial changes (a marker of DES host susceptibility).
CONCLUSIONS: These data raise the possibility that prenatal exposure to DES is associated with several common medical conditions in adulthood, although differential reporting by DES status and residual confounding cannot be ruled out. Further follow-up should assess these findings with validated outcomes and seek to understand the biological mechanisms.
Medical conditions among adult offspring prenatally exposed to diethylstilbestrol,NCBI, PMID: 23474687, 2013 May;24(3):430-8. doi: 10.1097/EDE.0b013e318289bdf7. Full text link.
Distilbène: l’interview de Sylvie, Réseau DES France
Tout a commençé avec un article de journal, paru en 1983, informant que le Distilbène engendrait des conséquences relativement graves sur les foetus de cette époque. A dix-sept ans, sur les conseils de ma mère, je suis allée consulter un gynécoloque… ”
Lisez la suite de l”interview de Sylvie Chevelier paru dans Ouest-France, Juin 2013.
DES, trois initiales qui ont bouleversé la vie de trois générations depuis les années 1950. Après vingt ans de combats judicaires, les victimes du distilbène ont à nouveau la parole. Pour la première fois en France, une étude épidémiologique sur les trois générations concernées est menée sur les effets de cette hormone de synthèse.
L’enquête nationale sur les conséquences du DES, commençée en avril 2013, cible notamment à évaluer le lien entre l’exposition au distilbène in-utero et le risque de développement du cancer du sein, et couvre les trois générations victimes de ce médicament.
In a joint project with students from Macquarie University, DES Action NSW is asking pharmacists to display the historic DES posters at their scripts-in counters to prompt people to find out about problems associated with exposure to diethylstilboestrol (DES).
So far 75 Sydney pharmacies have agreed to take part in the project but according to DES Action NSW co-ordinator Carol Devine the participation needs to be more widespread.