Autism Exposed Archives - DES Daughter Network

Prenatal Exposures: the vulnerable fetal Sperm and Egg

Effects of prenatal exposures to drugs on childhood development

” When a pregnant woman takes a drug, three generations are exposed simultaneously: the mother, the fetus, and, due to the fetal germline exposure, the future grandchildren. Far from being inert marbles of imperturbable DNA, fetal egg and sperm are sensitive and responsive to the uterine environment. This is largely due to a molecular phenomenon called “epigenetics,” which refers to the complex landscape of countless millions of tiny chemical switches that control gene expression. ”

Continue reading The vulnerable fetal Sperm and Egg
by Jill Escher from Autism Exposed.
DES studies on epigenetics and transgenerational effects.

We must be much better Caretakers of our Genetic Legacy

Jill Escher’s quest could help solve autism mystery

” Jill Escher, a dark-haired dynamo of smarts and stamina, was gently stopping her son, Jonny, 14, from ripping up the mail. He had just emptied spice bottles on the table to make finger paints. Upstairs, Escher’s daughter, Sophie, 7, was sending out incomprehensible cries. It could mean that Sophie had opened a box of crayons, eaten some and rubbed the rest into the carpet, or smeared a tube of toothpaste on the mirror. And while Escher tried to calm Sophie, Jonny could be tossing his iPad over the fence, tearing all the ivories off the piano, chewing the furniture or wandering out into traffic. ”

Continue reading We must be much better caretakers of our genetic legacy, by Jane Kay, with Jill Escher, 07 July 2013

Could a Pregnant Woman’s Exposure to Drugs alter the Brains of her GrandChildren?

A mom’s crusade could help unravel autism mystery

Something a pregnant woman is exposed to may alter not just her children, but also her grandchildren – and possibly even subsequent generations.
The power of pharmaceuticals to do just that came to light with DES, a synthetic estrogen that harmed at least two generations of offspring of women who took it.

Thanks to Jill Escher, scientists are considering how mothers taking fertility drugs in the 1950s and ’60s could be responsible for transgenerational abnormalities:

From generation to generation
A personal quest
Searching the epigenome for answers
Antidepressants under the microscope
FDA petitioned, NIH involved

Read A mom’s crusade could help unravel autism mystery
MNN Health News, 16 Jul 2013, feat. Jill Autism Exposed interview.

DES DiEthylStilbestrol Resources

DES studies on cancers and screening.
DES studies on epigenetics and transgenerational effects.
DES studies on fertility and pregnancy.
DES studies on gender identity and psychological health.
DES studies on in-utero exposure to DES and side-effects.
DES studies on the genital tract.
Papers on DES lawsuits.
DES videos and posts tagged DES, the DES-exposed, DES victims.

Prenatal exposures never dies

Diethylstilbestrol DES, the “safe and effective” multi-generational catastrophe

” Prenatal exposure to the once-popular synthetic estrogen drug DES caused a wide variety of developmental disturbances, including urogenital abnormalities, birth defects, infertility, altered gender behavior and identification, autoimmune diseases, psychiatric problems, vaginal cancer, cervical cancer, and breast cancer. Damage is now also confirmed in the grandchildren of the women who took the drugs. Though autism per se is not connected with this particular drug, the DES story provides an illustration of unforeseen multigenerational epigenetic impacts of synthetic hormone exposure. ”

Read Autism Exposed fantastic post, by Jill Escher, Feb 2013.

More DES DiEthylStilbestrol Resources

DES studies on cancers and screening.
DES studies on epigenetics and transgenerational effects.
DES studies on fertility and pregnancy.
DES studies on gender identity and psychological health.
DES studies on in-utero exposure to DES and side-effects.
DES studies on the genital tract.
Papers on DES lawsuits.
DES videos and posts tagged DES, the DES-exposed, DES victims.

Prenatal Exposures: should you be worried?

via “Prenatal Exposures Never Die”: the blog about epigenetics, autism, and the multigenerational tragedy of prenatal pharmaceutical use

My husband and I used IVF to get pregnant with twins, and the fertility clinic gave me several medications both before and after conception. Should I worry that any of these medications may have damaged the eggs of my daughter and sperm of my son?
I took antidepressants (20 mg of Paxil per day) throughout my pregnancy.
My son seems to be okay, but is there a risk of permanent damage to his sperm?
Diclegis, a drug to prevent morning sickness, was just approved as a Category A drug for pregnancy by the FDA.
Are there risks the FDA has not disclosed?

Jill Escher from Autism Exposed addresses those questions in PrenatalExposures.Blogspot.co.uk latest bog post…
read Prenatal Exposures: Should You Be Worried?

Find out more about DES exposure and the long-term health effects associated with prenatal exposure to DES drug.

DES DiEthylStilbestrol Resources

DES studies on cancers and screening.
DES studies on epigenetics and transgenerational effects.
DES studies on fertility and pregnancy.
DES studies on gender identity and psychological health.
DES studies on in-utero exposure to DES and side-effects.
DES studies on the genital tract.
Papers on DES lawsuits.
DES videos and posts tagged DES, the DES-exposed, DES victims.

The Consequences of Mass PreNatal Progestin Exposure, 1950s-70s

Worse than thalidomide?

” When we think of prenatal drug disasters, we usually think of the sedative thalidomide, which caused horrific birth defects, and synthetic estrogen DES, which caused cancer and infertility in offspring, among other horrors.

Ignored, however, have been the downstream effects of the extensive use of progestin drugs in obstetric and fertility practice from the late 1950s through today. Progestins, not estrogens, were the most widely used anti-miscarriage drugs during several decades of practice that placed near-unquestioning faith in modern pharmaceuticals combined with near-nonexistent concern about impacts on the fetus. ”

Read Worse than thalidomide?
by Jill Escher, Autism Exposed

DES DiEthylStilbestrol Resources

DES studies on cancers and screening.
DES studies on epigenetics and transgenerational effects.
DES studies on fertility and pregnancy.
DES studies on gender identity and psychological health.
DES studies on in-utero exposure to DES and side-effects.
DES studies on the genital tract.
Papers on DES lawsuits.
DES videos and posts tagged DES, the DES-exposed, DES victims.

Suspension of FDA Approval urged for new Morning Sickness Drug Diclegis

Another preventable future health tragedy?

Jill Escher, from Prenatal Exposures Never Die, the blog about epigenetics, autism, and the multigenerational tragedy of prenatal pharmaceutical use, wrote to the FDA on April 11. 2013.

“ I am writing to urgently request that the FDA take immediate steps to suspend approval for the prenatal drug Diclegis pending appropriate safety testing for impacts to fetal germ cells, the precursor cells to the baby’s egg or sperm. In addition, I urge the FDA to take immediate steps to issue warnings regarding potential germline impact of all prenatally administered drugs… ”

Read Suspension of Approval Urged for New Morning Sickness Drug, Diclegis, Pending Assessment of Fetal Germline Impacts, April 11. 2013.

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