Prenatal Exposures: the vulnerable fetal Sperm and Egg

Effects of prenatal exposures to drugs on childhood development

The vulnerable fetal sperm and egg
Autism Exposed: “The” blog about epigenetics, autism, and the multigenerational tragedy of prenatal pharmaceutical use – PrenatalExposures.Blogspot.co.uk

When a pregnant woman takes a drug, three generations are exposed simultaneously: the mother, the fetus, and, due to the fetal germline exposure, the future grandchildren. Far from being inert marbles of imperturbable DNA, fetal egg and sperm are sensitive and responsive to the uterine environment. This is largely due to a molecular phenomenon called “epigenetics,” which refers to the complex landscape of countless millions of tiny chemical switches that control gene expression. ”

We must be much better Caretakers of our Genetic Legacy

Jill Escher’s quest could help solve autism mystery

We must be much better caretakers of our genetic legacy
Follow Jill Escher via @Autism_Exposed

Jill Escher, a dark-haired dynamo of smarts and stamina, was gently stopping her son, Jonny, 14, from ripping up the mail. He had just emptied spice bottles on the table to make finger paints. Upstairs, Escher’s daughter, Sophie, 7, was sending out incomprehensible cries. It could mean that Sophie had opened a box of crayons, eaten some and rubbed the rest into the carpet, or smeared a tube of toothpaste on the mirror. And while Escher tried to calm Sophie, Jonny could be tossing his iPad over the fence, tearing all the ivories off the piano, chewing the furniture or wandering out into traffic. ”

Continue reading We must be much better caretakers of our genetic legacy, by Jane Kay, with Jill Escher, 07 July 2013

Related post: Could a Pregnant Woman’s Exposure to Drugs alter the Brains of her GrandChildren?

Could a Pregnant Woman’s Exposure to Drugs alter the Brains of her GrandChildren?

A mom’s crusade could help unravel autism mystery

A mom's crusade could help unravel autism mystery
Could a pregnant woman’s exposure to drugs alter the brains of her grandchildren?

Something a pregnant woman is exposed to may alter not just her children, but also her grandchildren – and possibly even subsequent generations.
The power of pharmaceuticals to do just that came to light with DES, a synthetic estrogen that harmed at least two generations of offspring of women who took it.

Thanks to Jill Escher, scientists are considering how mothers taking fertility drugs in the 1950s and ’60s could be responsible for transgenerational abnormalities:

  • From generation to generation
  • A personal quest
  • Searching the epigenome for answers
  • Antidepressants under the microscope
  • FDA petitioned, NIH involved

Read A mom’s crusade could help unravel autism mystery
MNN Health News, 16 Jul 2013, feat. Jill Autism Exposed interview.

DES DiEthylStilbestrol Resources

Prenatal exposures never dies

Diethylstilbestrol DES, the “safe and effective” multi-generational catastrophe

DES: The
DES tablets manufactured by Eli Lilly

Prenatal exposure to the once-popular synthetic estrogen drug DES caused a wide variety of developmental disturbances, including urogenital abnormalities, birth defects, infertility, altered gender behavior and identification, autoimmune diseases, psychiatric problems, vaginal cancer, cervical cancer, and breast cancer.  Damage is now also confirmed in the grandchildren of the women who took the drugs.  Though autism per se is not connected with this particular drug, the DES story provides an illustration of unforeseen multigenerational epigenetic impacts of synthetic hormone exposure. ”

Read Autism Exposed fantastic post, by Jill Escher, Feb 2013.

More DES DiEthylStilbestrol Resources

Prenatal Exposures: should you be worried?

via “Prenatal Exposures Never Die”: the blog about epigenetics, autism, and the multigenerational tragedy of prenatal pharmaceutical use

Prenatal Exposures: Should You Be Worried?
Autism Exposed: “The” blog about epigenetics, autism, and the multigenerational tragedy of prenatal pharmaceutical use – PrenatalExposures.Blogspot.co.uk

Jill Escher from Autism Exposed addresses those questions in PrenatalExposures.Blogspot.co.uk latest bog post…
read Prenatal Exposures: Should You Be Worried?

Find out more about DES exposure and the long-term health effects associated with prenatal exposure to DES drug.

DES DiEthylStilbestrol Resources

The Consequences of Mass PreNatal Progestin Exposure, 1950s-70s

Worse than thalidomide?

The consequences of mass prenatal progestin exposure, 1950s-70s
Worse than Thalidomide?

When we think of prenatal drug disasters, we usually think of the sedative thalidomide, which caused horrific birth defects, and synthetic estrogen DES, which caused cancer and infertility in offspring, among other horrors.

Ignored, however, have been the downstream effects of the extensive use of progestin drugs in obstetric and fertility practice from the late 1950s through today. Progestins, not estrogens, were the most widely used anti-miscarriage drugs during several decades of practice that placed near-unquestioning faith in modern pharmaceuticals combined with near-nonexistent concern about impacts on the fetus. ”

Read Worse than thalidomide?
by Jill Escher, Autism Exposed

DES DiEthylStilbestrol Resources

Suspension of FDA Approval urged for new Morning Sickness Drug Diclegis

Another preventable future health tragedy?

#Diclegis is #FDA approved to replace #Bendectin as new Morning Sickness DrugJill Escher, from Prenatal Exposures Never Die, the blog about epigenetics, autism, and the multigenerational tragedy of prenatal pharmaceutical use, wrote to the FDA on April 11. 2013.

I am writing to urgently request that the FDA take immediate steps to suspend approval for the prenatal drug Diclegis pending appropriate safety testing for impacts to fetal germ cells, the precursor cells to the baby’s egg or sperm. In addition, I urge the FDA to take immediate steps to issue warnings regarding potential germline impact of all prenatally administered drugs… ”

Read Suspension of Approval Urged for New Morning Sickness Drug, Diclegis, Pending Assessment of Fetal Germline Impacts, April 11. 2013.

Related post: Diclegis FDA approved to replace Bendectin as new Morning Sickness Drug: future Health Tragedy?.