Glyphosate : comment s’en sortir ?

Grande soirée événementielle d’Envoyé spécial – 17 janvier 2019

Peut-on sortir du glyphosate ? Pourquoi est-il aussi long et difficile d’interdire cet herbicide, considéré par de nombreux scientifiques comme dangereux pour la santé ?

Sommaire:

Envoyé spécial, un reportage exceptionnel présenté par Elise Lucet, publié sur YouTube le 21 janvier 2019.

Référence : “Envoyé spécial”. Glyphosate : comment s’en sortir ?.

Sri Lanka, un pays sans glyphosate

Le gouvernement a décidé en 2015 d’interdire le glyphosate, une mesure radicale unique au monde

Comment, dans les campagnes, les rizières, les plantations, a-t-on appris à vivre sans glyphosate ?

Le glyphosate, l’herbicide le plus vendu au monde, a fait couler beaucoup d’encre en 2017 et 2018.

Envoyé spécial, un reportage d’Elise Menand, Swanny Thiébaut, Cédric Baume et Marielle Krouk, publié sur YouTube le 23 janvier 2019.

Référence : “Envoyé spécial”. Glyphosate : comment s’en sortir ?.

(Bayer), Monsanto, et la fabrique du doute

Une firme, qui ne s’estime ni responsable ni coupable, et fait appel de ses condamnations ?

Les “Monsanto Papers” ont révélé comment le géant américain a fait rédiger en secret, par ses propres scientifiques, des études pour prouver que le glyphosate n’était pas dangereux.

Le glyphosate, l’herbicide le plus vendu au monde, a fait couler beaucoup d’encre en 2017 et 2018.

Envoyé spécial, un reportage de Tristan Waleckx, Guillaume Beaufils et Mikael Bozo publié sur YouTube le 22 janvier 2019.

Référence : “Envoyé spécial”. Glyphosate : comment s’en sortir ?.

Glypho or not glypho ?

Les agriculteurs concernés au premier chef

Vincent et Olivier sont tous les deux céréaliers, l’un est pro-glyphosate, l’autre 100% bio. Chacun va passer quelques jours dans l’exploitation de l’autre.

Le glyphosate, l’herbicide le plus vendu au monde, a fait couler beaucoup d’encre en 2017 et 2018.

Envoyé spécial, un reportage de Laura Aguirre de Carcer, Olivier Gardette, Marielle Krouk, publié sur YouTube le 21 janvier 2019.

Référence : “Envoyé spécial”. Glyphosate : comment s’en sortir ?.

Médecines alternatives et cancer : un commerce lucratif

Des charlatans profitent du désespoir de malades du cancer pour s’enrichir. Sans résultats pour les patients.

En Allemagne et en France, certains naturopathes et guérisseurs offrent des thérapies “alternatives” aux malades du cancer.

En compagnie d’un collègue prétendument atteint d’un lymphome de Hodgkin, la réalisatrice de ce documentaire a mené durant des mois un patient travail d’investigation pour mettre au jour les pratiques frauduleuses qui prospèrent sur la peur des patients.

Réalisation : Claudia Ruby, Allemagne, 2015. Référence.

Condom use in prevention of Human Papillomavirus infections and cervical neoplasia

Systematic review of longitudinal studies, 2014

HPV and cancer : the condom is much more effective than the vaccine in preventing cancer, including when dysplasias are already present. As a bonus, remember that the condom protects against a whole lot of other unpleasant infections or dangers…

Abstract

Objectives
Based on cross-sectional studies, the data on protection from Human Papillomavirus (HPV) infections related to using male condoms appear inconsistent. Longitudinal studies are more informative for this purpose. We undertook a systematic review of longitudinal studies on the effectiveness of male condoms in preventing HPV infection and cervical neoplasia.

Methods
We searched PubMed using MeSH terms for articles published until May 2013. Articles were included if they studied a change in non-immunocompromized women’s cervical HPV infection or cervical lesion status along with the frequency of condom use.

Results
In total, 384 abstracts were retrieved. Eight studies reported in 10 articles met the inclusion criteria for the final review. Four studies showed a statistically significantly protective effect of consistent condom use on HPV infection and on regression of cervical neoplasia. In the remaining four studies, a protective effect was also observed for these outcomes, although it was not statistically significant.

Conclusions
Consistent condom use appears to offer a relatively good protection from HPV infections and associated cervical neoplasia. Advice to use condoms might be used as an additional instrument to prevent unnecessary colposcopies and neoplasia treatments in cervical screening, and to reduce the risk of cervical cancer.

POLE-mutated clear cell cervical cancer associated with in-utero diethylstilbestrol exposure

Gynecologic Oncology Reports, Volume 28, Pages 15-17, May 2019

2019 Study Highlights

  • We report a POLE-mutated clear cell cervical cancer associated with in-utero DES.
  • Tumor exhibited increased tumor infiltrating lymphocytes and PD-L1 expression.
  • Patient remains in remission for ≥4 years after standard therapy.
  • POLE mutation confers a phenotype of higher immunogenicity and improved outcome.

Abstract

We report an extraordinary case of a woman, exposed to diethylstilbestrol in utero, who developed clear cell adenocarcinoma of the cervix with a concurrent polymerase-Ɛ (POLE) somatic mutation. The tumor exhibited the classic phenotypic characteristics of POLE-mutated tumors originating from other organs (e.g. the uterus or the colon) including increased tumor infiltrating lymphocytes and high PD-L1 expression and has remained in remission since completion of primary therapy for >4 years. This case highlights the importance of next generation sequencing in unraveling the biology of rare tumors and supports that the presence of a POLE mutation and the associated ultramutated state confers a unique phenotype of higher immunogenicity and possibly improved prognosis in a tissue-agnostic manner, i.e. regardless of the type of cancer where the POLE mutation is present. Image credit bioinfo.

DES DiEthylStilbestrol Resources

Does eating organic help prevent cancer ? You bet

Eating organic pesticide-free food significantly reduces cancer risk, study says

In a population-based cohort study of 68 946 French adults, a significant reduction in the risk of cancer was observed among high consumers of organic food.

Although the Association of Frequency of Organic Food Consumption With Cancer Risk / NutriNet-Santé Prospective Cohort Study Findings need to be confirmed, promoting organic food consumption in the general population could be a promising preventive strategy against cancer.

Eating organic pesticide-free food significantly reduces cancer risk

Association of Frequency of Organic Food Consumption With Cancer Risk – Findings From the NutriNet-Santé Prospective Cohort Study

Key Points

Question
What is the association between an organic food–based diet (ie, a diet less likely to contain pesticide residues) and cancer risk?

Findings
In a population-based cohort study of 68 946 French adults, a significant reduction in the risk of cancer was observed among high consumers of organic food.

Meaning
A higher frequency of organic food consumption was associated with a reduced risk of cancer; if the findings are confirmed, promoting organic food consumption in the general population could be a promising preventive strategy against cancer.

Abstract

Importance
Although organic foods are less likely to contain pesticide residues than conventional foods, few studies have examined the association of organic food consumption with cancer risk.

Objective
To prospectively investigate the association between organic food consumption and the risk of cancer in a large cohort of French adults.

Design, Setting, and Participants
In this population-based prospective cohort study among French adult volunteers, data were included from participants with available information on organic food consumption frequency and dietary intake. For 16 products, participants reported their consumption frequency of labeled organic foods (never, occasionally, or most of the time). An organic food score was then computed (range, 0-32 points). The follow-up dates were May 10, 2009, to November 30, 2016.

Main Outcomes and Measures
This study estimated the risk of cancer in association with the organic food score (modeled as quartiles) using Cox proportional hazards regression models adjusted for potential cancer risk factors.

Results
Among 68 946 participants (78.0% female; mean [SD] age at baseline, 44.2 [14.5] years), 1340 first incident cancer cases were identified during follow-up, with the most prevalent being 459 breast cancers, 180 prostate cancers, 135 skin cancers, 99 colorectal cancers, 47 non-Hodgkin lymphomas, and 15 other lymphomas. High organic food scores were inversely associated with the overall risk of cancer (hazard ratio for quartile 4 vs quartile 1, 0.75; 95% CI, 0.63-0.88; P for trend = .001; absolute risk reduction, 0.6%; hazard ratio for a 5-point increase, 0.92; 95% CI, 0.88-0.96).

Conclusions and Relevance
A higher frequency of organic food consumption was associated with a reduced risk of cancer. Although the study findings need to be confirmed, promoting organic food consumption in the general population could be a promising preventive strategy against cancer.

Up to half of childhood cancer survivors will develop hormone disorders

Endocrine Society’s Clinical Practice Guideline offers treatment recommendations

Washington, DC – The Endocrine Society issued a Clinical Practice Guideline titled “Hypothalamic-Pituitary and Growth Disorders in Survivors of Childhood Cancer: An Endocrine Society Clinical Practice Guideline,”advising healthcare providers on how to diagnose and treat the endocrine disorders that affect a significant portion of childhood cancer survivors in the United States today.

Recent data shows that almost 50 percent of these survivors will develop an endocrine disorder over their lifetime. The guideline provides recommendations on how to diagnose and manage certain endocrine and growth disorders commonly found in childhood cancer survivors.

Childhood cancer is relatively rare, and due to improvements in treatment and patient care, the current five-year survival rates exceed 80 percent. It’s estimated that by 2020, there will be half a million childhood cancer survivors in the United States. These survivors face a greater risk of developing serious medical complications, even decades after cancer treatment ends. Endocrine disorders are especially prevalent among this population, often as a result of their previous treatments, particularly exposure to radiation therapy.

“Childhood cancer survivors have a high risk of developing endocrine disorders,”

said Charles A. Sklar, M.D., of the Memorial Sloan Kettering Cancer Center in New York, N.Y. Sklar chaired the writing committee that developed the guideline.

“Our new guideline addresses the growing risk of endocrine disorders among childhood cancer survivors and suggests best practices for managing pituitary and growth disorders commonly found in this population. The guideline stresses the importance of life-long screening of these survivors for earlier detection and optimal patient care.”

Recommendations from the guideline include long-term screening of childhood cancer survivors who underwent radiation therapy to the brain. This population should be screened for growth disorders, pituitary hormone deficiencies, and early puberty. If a condition is diagnosed, in most instances, clinicians should treat these survivors with the same approaches as other patients who develop endocrine conditions.