Exposure to Diethylstilbestrol in the womb raises a woman’s risk of many cancers, according to a report published in the New England Journal of Medicine.
Researchers studied over 6500 women, 4600 of whom were exposed to DES in the womb. Results showed that this exposure significantly increased risk of many cancers and fertility problems, including a 40x increased risk of clear-cell adenocarcinoma, 8x increased risk of neonatal death, 2.4x increased risk of infertility and a 1.8x increased risk of breast cancer.
Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol
” … scientists at the National Institute of Environmental Health Sciences report that they have observed an increase in cancers, including cancer of the uterus, in female mice whose mothers were exposed to DES in utero — while in the uterus … ”
1998 Study Abstract
Prenatal exposure to diethylstilbestrol (DES) has been associated with the subsequent development of reproductive tract abnormalities, including poor reproductive outcome and neoplasia, in experimental animals and humans. Experimental animal studies with chemical carcinogens have raised the possibility that adverse effects of DES may be transmitted to succeeding generations. To evaluate this possibility and to determine if there is a sensitive window of developmental exposure, outbred CD-1 mice were treated with DES during three stages of development: group 1 was treated on days 9-16 of gestation (2.5, 5 or 10 microg/kg maternal body wt), the time of major organogenesis; group II was treated once on day 18 of gestation (1000 microg/kg maternal body wt) just prior to birth; group III was treated on days 1-5 of neonatal life (0.002 microg/pup/day). Female mice (F1) in each group were raised to sexual maturity and bred to control males. As previously reported, fertility of the F1 DES-exposed females was decreased in all groups. Female offspring (DES lineage or F2) from these matings were raised to maturity and housed with control males for 20 weeks. The fertility of these DES lineage female mice was not affected by DES exposure of their ‘grandmothers’. DES lineage mice were killed at 17-19 and 22-24 months of age. An increased incidence of malignant reproductive tract tumors, including uterine adenocarcinoma, was seen in DES lineage mice but not in corresponding controls; the range and prevalence of tumors increased with age. Because uterine adenocarcinomas were seen in all three DES groups, all developmental exposure periods were considered susceptible to the adverse effects of DES. These data suggest that the reduced fertility observed in the DES F1 female mice was not transmitted to their descendants; however, increased susceptibility to tumor formation is apparently transmitted to subsequent generations.
Read ‘DES Daughters’ Had Increased Rates Of Cancer; An Animal Study Shows ‘DES Granddaughters’ May Too, qajyjuvoma, Medical News, June 26, 2012.
2012: French researchers say they have uncovered new risks
Like DES, Bisphenol-A is a synthetic oestrogen with similar to identical effects on the human body.
Studies involving self-reporting by patients exposed to DES show an increased risk in many different autoimmune disorders, including autoimmune thyroid disorders – so the results of this BPA study are no surprise!
DES daughter Andrea Goldstein began a DES group in the 1970s. She compares DES with Thalidomide, a drug used in the 1950s to treat morning sickness in pregnant women and later found to cause severe birth defects.
Their injuries are on the outside. We are injured on the inside,” says Ms. Goldstein. “We might look fine, but we’re not.
And this is probably one of the reasons why there is so much silence around the DES issues … The consequences are not in your face and it’s all very intimate and personal …