A previously unknown Cent-1 molecule that kills cancer cells has been discovered by scientists.
The objective of the research was to accelerate the drug development process by identifying new compounds that would possess similar binding properties and cellular phenotype, but a different chemical structure, as the selected drugs in clinical use or investigational compounds in development.
The scientists combined computer-based screening and cell-based assays to create a method that can significantly accelerate drug discovery and thereby lower development costs.
- Finnish researchers discovered a new anticancer compound using accelerated drug screening process, VTT Technical Research Centre of Finland, News, 08.05.2014.
- Centmitor-1, a Novel Acridinyl-Acetohydrazide, Possesses Similar Molecular Interaction Field and Antimitotic Cellular Phenotype as Rigosertib, ON 01910.Na , American Association for Cancer Research, 13/5/1054 10.1158/1535-7163.MCT-13-0685, May 2014 13.