Association of Maternal Stilbestrol Therapy with Tumor Appearance in Young DES Daughters
1971 Study Abstract
Adenocarcinoma of the vagina in young women had been recorded rarely before the report of several cases treated at the Vincent Memorial Hospital between 1966 and 1969. The unusual occurrence of this tumor in eight patients born in New England hospitals between 1946 and 1951 led us to conduct a retrospective investigation in search of factors that might be associated with tumor appearance. Four matched controls were established for each patient; data were obtained by personal interview. Results show maternal bleeding during the current pregnancy and previous pregnancy loss were more common in the study group. Most significantly, seven of the eight mothers of patients with carcinoma had been treated with diethylstilbestrol started during the first trimester. None in the control group were so treated (p less than 0.00001). Maternal ingestion of stilbestrol during early pregnancy appears to have enhanced the risk of vaginal adenocarcinoma developing years later in the offspring exposed.
KwaliteitsCriteria bij Screenings-Protocol van DES-dochters
DES Centrum: ” Het jaar 2012 heeft niet alleen in het teken gestaan van verhuizing en reorganiseren. We hebben ons ook gericht op twee projecten. Het doel van beide projecten is te komen tot optimale medische zorg voor DES-dochters. ”
More than 99% of cases of cervical cancer are caused by the sexually transmitted human papillomavirus (HPV). Doctors say that because the new HPV tests find abnormalities – and increased risk of cancer – at an earlier stage, most women will be able to undergo smear tests far less often, after receiving a negative result.
” We’ve been doing the HPV test in our office for about 7 years,” said Dr. Jay Staub, ” and I’ve actually have negative paps for 5 to 7 to 10 years in a row and had an HPV test that was positive and actually had cervical cancer. So, I think we’re headed in that direction. We just don’t have the data yet. I think we’re going to see studies that indicate that the HPV test is probably more accurate as a primary screen. “
Cervical Cancer: Symptoms, Causes and Risks – EmpowHER
It is now 40 years since the connection between DES exposure and Cancer in DES Daughters was discovered. In the late 1960s, there was an unprecedented appearance of a rare vaginal cancer in young women. Cases of Clear Cell Adenocarcinoma (CCA) were diagnosed in an age group never before found to develop it.
Are you a probable DES Daughter? See this Chart and establish how much Risk you face!
A study of daughters of women given diethylstilbestrol, synthetic estrogen, during pregnancy has found that exposure to the drug while in the womb is associated with many reproductive problems and an increased risk of certain cancers.
DES is definitely no a drug of the past : this chart highlights the increased health risks associated with DES exposure, compared to the risks for women who were not exposed to DES in the womb.