Adenocarcinoma of the Vagina: Maternal Stilbestrol ingestion leading to future Cancer in Offspring

Association of Maternal Stilbestrol Therapy with Tumor Appearance in Young DES Daughters

1971 Study Abstract

image of Diethylstilbestrol DES clear cell adenocarcinoma CCA vaginal cancer
Diethylstilbestrol clear cell adenocarcinoma vaginal cancer

Adenocarcinoma of the vagina in young women had been recorded rarely before the report of several cases treated at the Vincent Memorial Hospital between 1966 and 1969. The unusual occurrence of this tumor in eight patients born in New England hospitals between 1946 and 1951 led us to conduct a retrospective investigation in search of factors that might be associated with tumor appearance. Four matched controls were established for each patient; data were obtained by personal interview. Results show maternal bleeding during the current pregnancy and previous pregnancy loss were more common in the study group. Most significantly, seven of the eight mothers of patients with carcinoma had been treated with diethylstilbestrol started during the first trimester. None in the control group were so treated (p less than 0.00001). Maternal ingestion of stilbestrol during early pregnancy appears to have enhanced the risk of vaginal adenocarcinoma developing years later in the offspring exposed.

Sources

Adenocarcinoma of the Vagina — Association of Maternal Stilbestrol Therapy with Tumor Appearance in Young Women, Arthur L. Herbst, M.D., Howard Ulfelder, M.D., and David C. Poskanzer, M.D., N Engl J Med 1971. Full article NEJM197104222841604 and PDF.

More DES DiEthylStilbestrol Resources

KwaliteitsCriteria: DES-dochters en Vrouwen met ClearCellAdenoCarcinoom

KwaliteitsCriteria bij Screenings-Protocol van DES-dochters

Kwaliteitscriteria DES-dochters en CCAC
Hier kunt u @DESCentrum tekst lezen, downloaden en eventueel printen

DES Centrum: ” Het jaar 2012 heeft niet alleen in het teken gestaan van verhuizing en reorganiseren. We hebben ons ook gericht op twee projecten. Het doel van beide projecten is te komen tot optimale medische zorg voor DES-dochters. ”

Lezen Kwaliteitscriteria DES-dochters en CCAC.

Kwaliteitscriteria vanuit het perspectief van vrouwen met een vorm van gynaecologische kanker
(volle tekst om te lezen, downloaden, printen).

More DES DiEthylStilbestrol Resources

After DES DiEthylStilbestrol : tracking the Harms of a Prenatal Drug Exposure

NCI Cancer Bulletin Archives 2011

After DES: Tracking the Harms of a Prenatal Drug Exposure
NCI Cancer Bulletin for October 18, 2011

Kari Christianson was 23 years old when she first heard of a drug called diethylstilbestrol, or DES.

It was the spring of 1972, and Dr. Arthur Herbst – who had recently published the study Adenocarcinoma of the Vagina — Association of Maternal Stilbestrol Therapy with Tumor Appearance in Young Women  suggesting that the drug, when used by pregnant women, might cause cancer in their offspring years later – was on television discussing concerns about the drug. For decades, doctors had prescribed DES to millions of healthy pregnant women, including Kari’s mother, based on unsubstantiated claims that it reduced the complications of pregnancy. “

Continue reading Kari’s story and Edward Winstead‘s post:
After DES: Tracking the Harms of a Prenatal Drug Exposure
NCI Cancer Bulletin for October 18, 2011.

More DES DiEthylStilbestrol Resources

HPV Tests for Cervical Cancer Detection in the UK

2012: NHS brings in new cervical cancer tests

NHS brings in new cervical cancer tests
HPV test will provide an early sign of an increased risk of cervical cancer

More than 99% of cases of cervical cancer are caused by the sexually transmitted human papillomavirus (HPV). Doctors say that because the new HPV tests find abnormalities – and increased risk of cancer – at an earlier stage, most women will be able to undergo smear tests far less often, after receiving a negative result.

Read NHS brings in new cervical cancer tests
by Laura Donnelly, Health Correspondent, Dec 2012

HPV Testing and Cervical Screening

Is the HPV Test better Cancer Screen Method than Pap Smear?

Many women know the HPV vaccine can help protect against cervical cancer. But did you know there is also an HPV test?.

  • Video by healthcentralobgyn, Published on 16 Dec 2011
  • We’ve been doing the HPV test in our office for about 7 years,” said Dr. Jay Staub, ” and I’ve actually have negative paps for 5 to 7 to 10 years in a row and had an HPV test that was positive and actually had cervical cancer. So, I think we’re headed in that direction. We just don’t have the data yet. I think we’re going to see studies that indicate that the HPV test is probably more accurate as a primary screen. “

Find out more

How to figure out if Women in their 20s had been exposed to DES in-Utero

Case Control Studies, Public Health, UC Berkeley Lecture 21, Oct 2012

Adenocarcinoma of the Vagina and in Utero Exposure to Diethyl stilbestrol DES

Epidemiologic Methods

  • The DES case study example is from 32:00 until 38:20.
  • Video published by UCBerkeley on YouTube.
More DES DiEthylStilbestrol Resources

Cervical Cancer Prevention has been a hot Topic for Women

Cervical Cancer: Symptoms, Causes and Risks – EmpowHER

Cervical Cancer Prevention has been a hot Topic for Women... See Risk Factors and CausesIt is now 40 years since the connection between DES exposure and Cancer in DES Daughters was discovered. In the late 1960s, there was an unprecedented appearance of a rare vaginal cancer in young women. Cases of Clear Cell Adenocarcinoma (CCA) were diagnosed in an age group never before found to develop it.

More info

Increased Risks Chart for Diethylstilbestrol-exposed Women (2nd Generation)

Are you a probable DES Daughter?
See this Chart and establish how much Risk you face!

Image courtesy of the National Cancer Institute.

A study of daughters of women given diethylstilbestrol, synthetic estrogen, during pregnancy has found that exposure to the drug while in the womb is associated with many reproductive problems and an increased risk of certain cancers.

DES is definitely no a drug of the past : this chart highlights the increased health risks associated with DES exposure, compared to the risks for women who were not exposed to DES in the womb.

Read Women exposed to Diethylstilbestrol in the Womb face increased Cancer Risk from the NIH/National Cancer Institute,
October 6, 2011.

More DES DiEthylStilbestrol Resources

Cervical and Vaginal Cancers are Higher Risk in Women exposed to DES in Utero

The large number of women exposed in utero to DES may still be at special risk for CCA as they grow older

Cervical and vaginal cancers are higher risk in women exposed to DES in uteroDES … the gift that keeps on giving! … Will the fear of cancer ever leave us?

Read Cervical and vaginal cancers are higher risk in women exposed to DES in utero.

Exposed to DES?

More info and Videos

More DES DiEthylStilbestrol Resources

DES, Drug of the Past?

Risks for DES exposed daughters compared to non-exposed
Is DES a drug of the past?

Not really, check out the chart highlighting today’s increased health risks…

Read Women exposed to Diethylstilbestrol in the Womb face increased Cancer Risk from the NIH/National Cancer Institute,
October 6, 2011