” Estrogens have important effects on bone turnover in both humans and experimental animals models. Moreover, the decreased level of estrogen after menopause appears to be one of the key factors in determining postmenopausal osteoporosis. The presence of estrogen receptor in both osteoblasts and osteoclasts has suggested a direct role of these steroid hormones on bone tissue. Thus, this tissue is now regarded as a specific estrogen target tissue. Exposure to estrogens during various stages of development has been shown to irreversibly influence responsive target organs. We have recently shown that transient developmental neonatal exposure (days 1-5 of life) of female mice to estrogen resulted in an augmented bone density in the adult animals. The aim of the present study was to evaluate whether short-term modification of maternal estrogen levels during pregnancy would induce changes in the skeleton of the developing fetuses and to identify any long-term alterations that may occur. Pregnant mice were injected with varying doses (0.1-100 micrograms/kg maternal BW) of the synthetic estrogen diethylstilbestrol (DES) from day 9-16 of pregnancy. Offspring were weaned at 21 days of age, and effects on bone tissue of the female mice were evaluated in adulthood (6-9 months of age). Prenatal DES treatment(s) did not significantly affect BW. However, a dose-dependent increase in bone mass, both in the trabecular and cortical compartments, was observed in the prenatal DES-exposed female offspring. Furthermore, long bones of DES-exposed females were shorter than controls. Normal skeletal mineralization accompanied these changes in the bone tissue, as shown by a parallel increase in skeletal calcium content. Double tetracycline labeling performed in 6-month-old DES-exposed animals showed an increase in mineral apposition rate in adult DES-exposed mice as compared with untreated control animals, although no significant difference in the circulating estrogen levels was found in animals of this age. Experiments were then performed to evaluate whether perturbation of the estrogen surge at puberty in these diethylstilbestrol (DES)-exposed mice could reverse the observed changes. Femur length was chosen as a marker of potential estrogenic effect. Prepubertal ovariectomy of the prenatally DES-treated animals could only partially reverse the effects observed in the skeleton of the DES-treated animals. Further experiments were performed to evaluate whether these changes could have occurred in utero. CD-1 pregnant female mice were injected with DES (100 micrograms/kg maternal BW) from days 9-15 of gestation. On day 16 of gestation, fetuses were examined and stained by a standard Alizarin Red S and Alcian Blue procedure to visualize calcified and uncalcified skeletal tissue. Estrogen treatment induced an increase in the amount of calcified skeleton as compared with untreated controls and also a decrease in the length of long bones, strongly suggesting a change in both endochondral ossification and endosteal and periosteal bone formation. In summary, these data show, for the first time, that alterations in the maternal estrogenic levels during pregnancy can influence early phases of fetal bone tissue development and subsequently result in permanent changes in the skeleton. Finally, the effect of this short-term estrogen treatment can be seen in the fetal skeleton, suggesting an estrogen-imprinting effect on bone cell-programming in fetal life because treatment effects on bone cell turnover can be observed later in adult life. ”
Les “petits-garçons DES” issus de “grands-mères distilbène” sont 40 à 50 fois plus exposés au risque de malformations du pénis
Une étude montre que les petits-enfants des femmes traitées avec l’hormone de synthèse Distilbène® DES, médicament prescrit aux femmes enceintes jusqu’à la fin des années 70 et sensé prevenir les fausses couches, sont 40 à 50 fois plus exposés au risque de malformations du pénis.
Endometriosis occurs when endometrial cells grow where they shouldn’t – in places other than the uterus lining. It is estimated that up to 10% of women, or more, suffer endometriosis. Some studies have recently indicated that molecules from plastic, that break down in heat, can mimic estrogen, and may contribute to hormone problems, such as endometriosis. The rate of endometriosis is estimated to be 80% greater in women exposed to DiEthylStilbestrol in utero.
Are you a probable DES Daughter? See this Chart and establish how much Risk you face!
A study of daughters of women given diethylstilbestrol, synthetic estrogen, during pregnancy has found that exposure to the drug while in the womb is associated with many reproductive problems and an increased risk of certain cancers.
DES is definitely no a drug of the past : this chart highlights the increased health risks associated with DES exposure, compared to the risks for women who were not exposed to DES in the womb.
Want to know more about the pregnancy drug DiEthylStilbestrol?
New AFSSAPS DES survey and update DES historical facts, current issues, risks associated with DES exposure, breast cancer risks, post adolescent psychiatric disorders, risks for the 3rd generation, DES pregnancy care.
DES Sons Numbers and Health Concerns Although less is known about the consequences of diethylstilbestrol exposure in men than in women, important DES health concerns have been identified.
DES Sons Studies The most common reported health issues in DES sons studies are epididymal cysts, testicular problems, testicular cancer, infertility, psychological and neurological effects.
Gender Identity and DES Exposure Dr. Dana Beyer radio interview on the significant evidence linking prenatal Diethylstilbestrol DES exposure with gender identity and transsexual development.