Children born from IVF or in vitro fertilization increased risk of developing cancer . Research results of scientists from Denmark indicates that babies born from fertility treatment outcomes 33 percent higher chance of suffering from cancer since she was a childhood .
Types of cancer are also not arbitrary . According to research , these babies are 65 percent greater risk of suffering from blood cancer ( leukemia ) , and 88 percent greater brain cancer and central nervous system .
Objective To clarify the association between fertility treatment and the risk for cancer in children.
Patient(s) Twenty-five cohort and case-control studies involving children born after fertility treatment as the exposure of interest and cancer as the outcome.
Main Outcome Measure(s) Medline was searched through September 2012 to identify relevant studies. The study-specific estimates for each cancer outcome were combined into a pooled relative risk (RR) with 95% confidence interval (CI) by a meta-analytic approach.
Result(s) We found that children born after fertility treatment were at increased risk for all cancers (RR = 1.33; 95% CI, 1.08–1.63) and for hematological cancers (RR = 1.59; 95% CI, 1.32–1.91), central nervous system/neural cancers (RR = 1.88; 95% CI, 1.02–3.46), and other solid cancers (RR = 2.19; 95% CI, 1.26–3.80). For specific cancer types, we found increased risks for leukemias (RR = 1.65; 95% CI, 1.35–2.01), neuroblastomas (RR = 4.04; 95% CI, 1.24–13.18), and retinoblastomas (RR = 1.62; 95% CI, 1.12–2.35) associated with fertility treatment.
Conclusion(s) The results of the largest meta-analysis on this topic to date indicate an association between fertility treatment and cancer in offspring. However, our results do not rule out that factors related to underlying subfertility, rather than the procedure itself, are the most important predisposing factors for childhood cancer.
Studies of donor oocytes and the risk of adverse perinatal outcomes have provided inconsistent results
The probability of a pregnancy resulting in a healthy live birth decreases as women age, particularly after age 35 years. The likelihood of a spontaneous conception decreases, whereas the risks of miscarriage and a range of late obstetric and perinatal complications increase. Assisted reproductive technology (ART) has allowed many couples who would otherwise be unable to have children to have successful pregnancies, but the age-related biological barriers to establishing an ongoing pregnancy that result from increasing maternal age have been difficult to overcome, even with transfer of multiple embryos. However, although multiple-embryo transfer increases the chances of pregnancy, it also increases the likelihood of adverse pregnancy outcomes, particularly those related to preterm delivery. In addition, ART is associated with an increased risk of adverse obstetric and perinatal outcomes compared with spontaneous conception, even with singleton pregnancies, although the relative contribution of ART vs the underlying cause of infertility to these outcomes is unclear. For couples unable to achieve a successful pregnancy through ART with autologous oocytes, presumably because of idiopathic or age-related declines in ovarian reserve, the use of donor oocytes provides an alternative to replacement of multiple embryos derived from autologous oocytes (or an additional option after unsuccessful cycles with multiple embryos). Although the use of donor oocytes increases the probability of conception and live birth in older women,7 studies of donor oocytes and the risk of adverse perinatal outcomes have provided inconsistent results.
The prevalence of oocyte donation for in vitro fertilization (IVF) has increased in the United States – from +- 8,000 cycle attempts using donor eggs in 2000 to +/- 18,000 cycle attempts using donor eggs in 2010 – but little information is available regarding maternal or infant outcomes to improve counseling and clinical decision making.
Study Clarifies Link Between Fertility Treatments and Neurological Problems In Kids
BACKGROUND: The effect of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) on the developing human brain is unclear. The objective of this study is to evaluate neurodevelopmental (ND) outcome of children born following these techniques.
METHODS: This systematic review includes studies which compare a group of children born following IVF/ICSI to children born after natural conception by assessing outcome in terms of neuromotor development, cognition, speech/language and behaviour. Specific attention is paid to the studies’ methodological quality based on study design, attrition, blinding of the assessor, validity of ND tests used, confounders included and group size or power analysis.
RESULTS: Twenty-three out of 59 studies had a good methodological quality including 9 register-based (RB) and 14 controlled studies. RB studies suggested that IVF/ICSI per se does not increase the risk for severe cognitive impairment (i.e. mental retardation) or neuromotor handicaps such as cerebral palsy (CP), the association of IVF/ICSI and CP being brought about by the association of assisted conception with risk factors, like preterm birth. In general, controlled studies of good quality did not report an excess of ND disorders in IVF/ICSI-children. However, the majority of studies followed the children during infancy only, thereby precluding pertinent conclusions on the risk of ND disorders that come to the expression at older ages, such as fine manipulative disability or dyslexia.
CONCLUSIONS: A negative effect of assisted conception on the developing human brain is not identified; however, further research of high methodological quality in children beyond pre-school age is needed.
Intended as a message of hope rather than a ‘how to’ book, A Dream Come True is the inspiring story of one woman’s path to motherhood via fertility treatment using a donated embryo.
Kitty Alexander describes the torment of not being able to have a child naturally, the other routes to parenthood she tried and considered and the process of her fertility treatment. She then moves on to describe the joy of pregnancy and birth, and to the way she has told her son the truth about his origins.
A Dream Come True includes the story she wrote for her son in which she explains everything to him. A deeply positive book, the author hopes it will inspire women who, like her, know what it is like to be faced with an unstoppable tide of longing to become a parent.
The research, led by British scientists, has also shown for the first time that the technique increased the number of babies born as a result. Gently scratching the lining of the womb in the month before IVF treatment was shown to increase in the clinical pregnancy rate of women undergoing IVF to 49 per cent, compared with the current average of 29 per cent.
OBJECTIVE: To examine prenatal diethylstilbestrol (DES) exposure in relation to male reproductive outcomes.
DESIGN: Prospective observational study.
SETTING: Participants were identified through record review, clinical trial participation, or an obstetrics clinic.
PATIENT(S): A total of 1,085 DES-exposed and 1,047 unexposed men.
INTERVENTION(S): Participants were exposed prenatally to DES through the mother’s obstetrics care or clinical trial participation.
MAIN OUTCOME MEASURE(S): Infertility; never fathering a pregnancy or live birth; number of pregnancies or live births fathered.
RESULT(S): We found little evidence that prenatal DES exposure affects the likelihood of never fathering a pregnancy or live birth, or influences the mean number of fathered pregnancies or live births. Our data suggest that DES-exposed men are slightly more likely to experience infertility (relative risk [RR] = 1.3, 95% confidence interval [CI] = 1.0-1.6). The DES dose and gestational timing did not influence infertility or the number of pregnancies or live births fathered, but results were inconsistent for dose effects on the likelihood of never fathering a pregnancy or a live birth.
CONCLUSION(S): Prenatal DES exposure may be associated with a slightly increased risk of having an infertility experience, but does not increase the likelihood of never fathering a pregnancy or a live birth, or the number of pregnancies or live births fathered.
Reproductive Outcomes in Men with prenatal Exposure to DiEthylStilbestrol, NCBI, Dr R Hoover, PMID:16359959, Dec 2005.
DES-exposed women have a higher risk of infertility
2001 Study Abstract
Although it is well established that women exposed to diethylstilbestrol in utero have an increased risk of spontaneous abortion, ectopic pregnancy, and preterm delivery, it is not known whether they also have an increased risk of infertility. The authors assessed this question in data from a collaborative follow-up study of the offspring of women who took diethylstilbestrol during pregnancy. In 1994, 1,753 diethylstilbestrol-exposed and 1,050 unexposed women from an ongoing cohort study (National Cooperative Diethylstilbestrol Adenosis Study and Dieckmann cohorts) provided data on difficulties in conceiving and reasons for the difficulty. Age-adjusted relative risks were computed for the association of diethylstilbestrol exposure with specific types of infertility. A greater proportion of exposed than unexposed women were nulligravid (relative risk (RR) = 1.3, 95% confidence interval (CI): 1.1, 1.5), and a greater proportion had tried to become pregnant for at least 12 months without success (RR = 1.8, 95% CI: 1.6, 2.1). Diethylstilbestrol exposure was significantly associated with infertility due to uterine and tubal problems, with relative risks of 7.7 (95% CI: 2.3, 25) and 2.4 (95% CI: 1.2, 4.6), respectively. The present findings indicate that diethylstilbestrol-exposed women have a higher risk of infertility than do unexposed women and that the increased risk of infertility is primarily due to uterine or tubal problems.
Sadly for many DES daughters having their own children is not possible! Many of us who have experienced miscarriages, want to have kids but are struggling or unable to…
Infertility among women exposed prenatally to diethylstilbestrol,NCBI, PMID: 11495854, 2001 Aug 15;154(4):316-21. Full text: Oxford Journals Medicine & Health International Journal of Epidemiology link.
Evidence de perturbations hormonales chez des ouvriers exposés, dans le cadre professionnel, aux phtalates
Une étude parue en mars 2012 sur le site de la revue britannique Human Reproduction met en évidence que l’exposition des testicules de l’homme adulte aux phtalates – un plastifiant – entraîne une inhibition de la production de l’hormone masculine, la testostérone. Jusqu’ici, un tel effet n’avait été constaté que sur les testicules de fœtus humain ou chez le rongeur.
Slightly higher Rate of Mental Retardation, study says
Does IVF make children more vulnerable to certain cognitive or other developmental issues? In the largest study to date looking at the connection between IVF procedures and neurological disorders, scientists found a small but significant risk of intellectual disabilities among twins and triplets, though not among singleton births.
Baby Conceived Using Oldest ‘Rainy Day’ Sperm Frozen Since 1987
Baby’s father, Richard Pott, developed testicular cancer when he was 21 and doctors advised he freeze samples of sperm before embarking on treatment that might leave him infertile…
Although becoming a father wasn’t a priority for him then, 25 years later – the longest that sperm has been kept frozen and then successfully used for IVF in the UK – Richard got to finally use his frozen sperm to become father to daughter Vivienne.