IMMDS Review listens to Dr Jesse Olszynko-Gryn about Primodos

Independent Medicines and Medical Devices Safety Review Oral Hearing, 26th November 2018

The Independent Medicines and Medical Devices Safety Review is Chaired by Baroness Julia Cumberlege CBE DL.

In February 2018, the Secretary of State for Health and Social Care, the Rt Hon Jeremy Hunt MP, announced a review into how the health system responds to reports from patients about harmful side effects from medicines and medical devices. The announcement in the House of Commons follows patient-led campaigns on the use of the hormone pregnancy test Primodos, anti-epileptic drug sodium valproate and surgical mesh.

About Primodos

  • Read and/or download the full study (free access) Oral hormone pregnancy tests and the risks of congenital malformations: a systematic review and meta-analysis, F1000Research, First published 31 Oct 2018, 7:1725, DOI:10.12688/f1000research.16758.1.
  • Read and/or download the full study (free access) The Primodos components Norethisterone acetate and Ethinyl estradiol induce developmental abnormalities in zebrafsh embryos, nature, Published 13 Feb 2018, DOI:10.1038/s41598-018-21318-9.
  • To read some real stories told by the Primodos victims, go to this post comment section.  Read our posts tagged primodos.

IMMDS Review listens to Professor Carl Heneghan about Primodos Studies

Independent Medicines and Medical Devices Safety Review Oral Hearing, 27th November 2018

The Independent Medicines and Medical Devices Safety Review is Chaired by Baroness Julia Cumberlege CBE DL.

In February 2018, the Secretary of State for Health and Social Care, the Rt Hon Jeremy Hunt MP, announced a review into how the health system responds to reports from patients about harmful side effects from medicines and medical devices. The announcement in the House of Commons follows patient-led campaigns on the use of the hormone pregnancy test Primodos, anti-epileptic drug sodium valproate and surgical mesh.

About Primodos

  • Read and/or download the full study (free access) Oral hormone pregnancy tests and the risks of congenital malformations: a systematic review and meta-analysis, F1000Research, First published 31 Oct 2018, 7:1725, DOI:10.12688/f1000research.16758.1.
  • Read and/or download the full study (free access) The Primodos components Norethisterone acetate and Ethinyl estradiol induce developmental abnormalities in zebrafsh embryos, nature, Published 13 Feb 2018, DOI:10.1038/s41598-018-21318-9.
  • To read some real stories told by the Primodos victims, go to this post comment section.  Read our posts tagged primodos.

IMMDS Review listens to Journalist Jason Farrell about Primodos

Independent Medicines and Medical Devices Safety Review Oral Hearing, 26th November 2018

The Independent Medicines and Medical Devices Safety Review is Chaired by Baroness Julia Cumberlege CBE DL.

In February 2018, the Secretary of State for Health and Social Care, the Rt Hon Jeremy Hunt MP, announced a review into how the health system responds to reports from patients about harmful side effects from medicines and medical devices. The announcement in the House of Commons follows patient-led campaigns on the use of the hormone pregnancy test Primodos, anti-epileptic drug sodium valproate and surgical mesh.

About Primodos

  • Read and/or download the full study (free access) Oral hormone pregnancy tests and the risks of congenital malformations: a systematic review and meta-analysis, F1000Research, First published 31 Oct 2018, 7:1725, DOI:10.12688/f1000research.16758.1.
  • Read and/or download the full study (free access) The Primodos components Norethisterone acetate and Ethinyl estradiol induce developmental abnormalities in zebrafsh embryos, nature, Published 13 Feb 2018, DOI:10.1038/s41598-018-21318-9.
  • To read some real stories told by the Primodos victims, go to this post comment section.  Read our posts tagged primodos.

IMMDS Review listens to Professor Neil Vargesson about Primodos Studies

Independent Medicines and Medical Devices Safety Review Oral Hearing, 27th November 2018

The Independent Medicines and Medical Devices Safety Review is Chaired by Baroness Julia Cumberlege CBE DL.

In February 2018, the Secretary of State for Health and Social Care, the Rt Hon Jeremy Hunt MP, announced a review into how the health system responds to reports from patients about harmful side effects from medicines and medical devices. The announcement in the House of Commons follows patient-led campaigns on the use of the hormone pregnancy test Primodos, anti-epileptic drug sodium valproate and surgical mesh.

About Primodos

  • Read and/or download the full study (free access) Oral hormone pregnancy tests and the risks of congenital malformations: a systematic review and meta-analysis, F1000Research, First published 31 Oct 2018, 7:1725, DOI:10.12688/f1000research.16758.1.
  • Read and/or download the full study (free access) The Primodos components Norethisterone acetate and Ethinyl estradiol induce developmental abnormalities in zebrafsh embryos, nature, Published 13 Feb 2018, DOI:10.1038/s41598-018-21318-9.
  • To read some real stories told by the Primodos victims, go to this post comment section.  Read our posts tagged primodos.

IMMDS Review listens to the Association for Children damaged by Hormone Pregnancy Tests

Independent Medicines and Medical Devices Safety Review Oral Hearing, 26th November 2018

The Independent Medicines and Medical Devices Safety Review is Chaired by Baroness Julia Cumberlege CBE DL.

In February 2018, the Secretary of State for Health and Social Care, the Rt Hon Jeremy Hunt MP, announced a review into how the health system responds to reports from patients about harmful side effects from medicines and medical devices. The announcement in the House of Commons follows patient-led campaigns on the use of the hormone pregnancy test Primodos, anti-epileptic drug sodium valproate and surgical mesh.

About Primodos

  • Read and/or download the full study (free access) Oral hormone pregnancy tests and the risks of congenital malformations: a systematic review and meta-analysis, F1000Research, First published 31 Oct 2018, 7:1725, DOI:10.12688/f1000research.16758.1.
  • Read and/or download the full study (free access) The Primodos components Norethisterone acetate and Ethinyl estradiol induce developmental abnormalities in zebrafsh embryos, nature, Published 13 Feb 2018, DOI:10.1038/s41598-018-21318-9.
  • To read some real stories told by the Primodos victims, go to this post comment section.  Our posts tagged primodos.

Pesticide residues found in 98 percent of Canadian honey samples

Determination of glyphosate, AMPA, and glufosinate in honey by online solid-phase extraction-liquid chromatography-tandem mass spectrometry

A new study is the latest evidence that glyphosate herbicides are so pervasive that residues can be found in foods not produced by farmers using glyphosate.

As U.S. regulators continue to dance around the issue of testing foods for residues of glyphosate weed killers, government scientists in Canada have found the pesticide in 197 of 200 samples of honey they examined, Environmental Health News reports, March 22, 2019.

ABSTRACT

A simple method was developed for the simultaneous determination of glyphosate, its main degradation product (aminomethylphosphonic acid), and glufosinate in honey. Aqueous honey solutions were derivatised offline prior to direct analysis of the target analytes using online solid-phase extraction coupled to liquid chromatography-tandem mass spectrometry. Using the developed procedure, accuracies ranging from 95.2% to 105.3% were observed for all analytes at fortification levels of 5, 50, and 150 μg kg−1 with intra-day precisions ranging from 1.6% to 7.2%. The limit of quantitation (LOQ) was 1 μg kg−1 for each analyte. Two hundred honey samples were analysed for the three analytes with AMPA and glyphosate being most frequently detected (99.0% and 98.5% of samples tested, respectively). The concentrations of glyphosate were found to range from <1 to 49.8 μg kg−1 while those of its degradation product ranged from <1 to 50.1 μg kg−1. The ratio of glyphosate to AMPA was found to vary significantly amongst the samples where both analytes were present above the LOQ. Glufosinate was detected in 125 of 200 samples up to a maximum concentration of 33.0 μg kg−1.

An agroecological Europe in 2050: multifunctional agriculture for healthy eating

Findings from the Ten Years For Agroecology (TYFA) modelling exercise

The Independent Institution for Sustainable Development and International Relations (IDDRI) published its “Ten Years for Agroecologyresearch, showing that a transition to a kind of agriculture that is free from synthetic chemistry is absolutely realistic.

AGROECOLOGY: AN AMBITIOUS AND SYSTEMIC PROJECT

Jointly addressing the challenges of sustainable food for Europeans, the preser-vation of biodiversity and natural resources and the fight against climate change requires a profound transition of our agricultural and food system. An agroeco-logical project based on the phasing-out of pesticides and synthetic fertilizers, and the redeployment of extensive grasslands and landscape infrastructure would allow these issues to be addressed in a coherent manner.

AN ORIGINAL MODELLING OF THE EUROPEAN FOOD SYSTEM

The TYFA project explores the possibility of generalising such agroecology on a European scale by analysing the uses and needs of current and future agri-cultural production. An original quantitative model (TYFAm), linking on a systemic manner agricultural production, production methods and land use, makes it possible to analyse retrospectively the functioning of the European food system and to quantify an agroecological scenario by 2050 by testing the implications of different hypotheses.

PROSPECTS FOR A LESS PRODUCTIVE AGROECOLOGICAL SYSTEM

Europe’s increasingly unbalanced and over-rich diets, particularly in animal products, contribute to the increase in obesity, diabetes and cardiovascular diseases. They are based on intensive, highly dependent agriculture: (i) synthetic pesticides and fertilizers—with proven health and environmental conse- quences; (ii) imports of vegetable proteins for animal feed—making Europe a net importer of agricultural land. A change in diet less rich in animal products thus opens up prospects for a transition to an agroecology not bound to main-tain current yields, thus opening new fields for environmental management.

SUSTAINABLE FOOD FOR 530 MILLION EUROPEANS

The TYFA scenario is based on the widespread adoption of agroecology, the phasing-out of vegetable protein imports and the adoption of healthier diets by 2050. Despite an induced drop in production of 35% compared to 2010 (in Kcal), this scenario: – provides healthy food for Europeans while maintaining export capacity; – reduces Europe’s global food footprint; – leads to a 40% reduction in GHG emissions from the agricultural sector; – regains biodiversity and conserves natural resources.Further work is needed and underway on the socio-economic and policy impli-cations of the TYFA scenario.

Nanoplastics damage marine creatures’ natural defences, increasing lethal effects of POPs

Nanoplastic Ingestion Enhances Toxicity of Persistent Organic Pollutants (POPs) in the Monogonont Rotifer Brachionus koreanus via Multixenobiotic Resistance (MXR) Disruption

Nano-sized particles of plastic can be more damaging to marine species than larger sized microplastics, a new study shows.

Lab tests revealed that nanoplastics can damage cell membranes in tiny marine creatures called rotifers (Rotifera), disrupting their natural defences against toxicants.

The researchers found that rotifers that had been exposed to nanoparticles of polystyrene were significantly more susceptible to the lethal effects of persistent organic pollutants (POPs). Reference.

Abstract

Among the various materials found inside microplastic pollution, nanosized microplastics are of particular concern due to difficulties in quantification and detection; moreover, they are predicted to be abundant in aquatic environments with stronger toxicity than microsized microplastics. Here, we demonstrated a stronger accumulation of nanosized microbeads in the marine rotifer Brachionus koreanus compared to microsized ones, which was associated with oxidative stress-induced damages on lipid membranes. In addition, multixenobiotic resistance conferred by P-glycoproteins and multidrug resistance proteins, as a first line of membrane defense, was inhibited by nanoplastic pre-exposure, leading to enhanced toxicity of 2,2′,4,4′-tetrabromodiphenyl ether and triclosan in B. koreanus. Our study provides a molecular mechanistic insight into the toxicity of nanosized microplastics toward aquatic invertebrates and further implies the significance of synergetic effects of microplastics with other environmental persistent organic pollutants.

The early-life exposome: Description and patterns in six European countries

Exploring the exposome: study measures multitude of environmental influences on health

Scientists have measured how children and pregnant women are exposed to over 120 environmental factors influencing our health — from air and noise pollution to green space and access to public transport.

The study gathered and analysed data from six European countries to build a picture of the ‘exposome’ — the array of environmental factors that humans are exposed to from the moment they are conceived.

A better understanding of the exposome could help us understand the role of the environment in the onset of various diseases, including cancer and other chronic disorders such as cardiovascular disease. Reference.

Highlights

  • The early-life exposome is high dimensional and not easily reducible to fewer components.
  • Correlations between exposures within the same exposure group can be high.
  • Correlations between exposures in different exposure groups are low.
  • The exposome varies strongly by location and by life period.

Abstract

Characterization of the “exposome”, the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases.

Here, we aimed to describe the early-life exposome. Specifically, we focused on the correlations between multiple environmental exposures, their patterns and their variability across European regions and across time (pregnancy and childhood periods). We relied on the Human Early-Life Exposome (HELIX) project, in which 87 environmental exposures during pregnancy and 122 during the childhood period (grouped in 19 exposure groups) were assessed in 1301 pregnant mothers and their children at 6–11 years in 6 European birth cohorts.

Some correlations between exposures in the same exposure group reached high values above 0.8. The median correlation within exposure groups was >0.3 for many exposure groups, reaching 0.69 for water disinfection by products in pregnancy and 0.67 for the meteorological group in childhood. Median correlations between different exposure groups rarely reached 0.3. Some correlations were driven by cohort-level associations (e.g. air pollution and chemicals). Ten principal components explained 45% and 39% of the total variance in the pregnancy and childhood exposome, respectively, while 65 and 90 components were required to explain 95% of the exposome variability. Correlations between maternal (pregnancy) and childhood exposures were high (>0.6) for most exposures modeled at the residential address (e.g. air pollution), but were much lower and even close to zero for some chemical exposures.

In conclusion, the early life exposome was high dimensional, meaning that it cannot easily be measured by or reduced to fewer components. Correlations between exposures from different exposure groups were much lower than within exposure groups, which have important implications for co-exposure confounding in multiple exposure studies. Also, we observed the early life exposome to be variable over time and to vary by cohort, so measurements at one time point or one place will not capture its complexities.

Fracking waste commonly used in commercial applications

Is liquid waste from oil and gas operations on your sidewalk or in your pool ?

“They’ve spread it on roads. They’ve irrigated almond farms and fruit groves with it. The oil and gas industry’s liquid waste has been used for a variety of commercial and industrial purposes over the years. But never has the “beneficial use” of this waste stream been so grossly applied, or so close to home, as it is today.

Meet Eureka Resources and Nature’s Own Source. Both of these companies have attracted attention by processing liquid waste from oil and gas operations and creating commercial products for use in pools and on roads, sidewalks, patios, stairs or anywhere else a consumer may put it. “

Read Is Drilling and Fracking Waste on Your Sidewalk or in Your Pool?, February 21, 2019. Image credit Clorox® Pool&Spa™.