A Comparison of Pregnancy Experience in DES-exposed and DES-unexposed Daughters

In this 1980 study, the difference in pregnancy outcomes between the DES daughters and the unexposed is highly significant

A comparison of pregnancy experience in DES-exposed and DES-unexposed daughters
Pregnancy outcomes in DES Daugters are worse than those in unexposed women

Reproductive histories were compared for 226 diethylstilbestrol-exposed daughters and 203 DES-unexposed daughters whose mothers participated in a double-blind evaluation 27 years before. Irregular menstruation was slightly more common among the exposed (10%) than among the unexposed (4%). Nineteen of the exposed and only four of the unexposed had primary infertility. Among those at risk, 86% of the unexposed and 67% of the exposed had become pregnant. The reasons for these differences are not known. Comparison of evaluable first pregnancy outcome revealed full-term live birth to be more common among the unexposed (85%) than the exposed (47%). Premature live birth was experienced by 22% of the exposed but only 7% of the unexposed. Nonviable outcomes of stillbirth, neonatal death, miscarriage and ectopic pregnancy occurred in 31% of the exposed and 8% of the unexposed. The difference in pregnancy outcomes between the groups is highly significant. The DES-exposed with transverse cervicovaginal ridges were more likely to experience a nonviable outcome. Overall 82% of the exposed and 93% of the unexposed had at least one live offspring.

Sources: A comparison of pregnancy experience in DES-exposed and DES-unexposed daughters, NCBI, Dr Herbst A, Feb 1980

Related post: Continued follow-up of #Pregnancy Outcomes in #DiEthylStilbestrol-exposed Offspring, by Dr Herbst A, Oct 2000

Sadly for many DES daughters having their own children is not possible! Many of us who have experienced miscarriages, want to have kids but are struggling or unable to…
More about DES pregnancy risks – our posts tagged pregnancy

More DES DiEthylStilbestrol Resources

Continued follow-up of Pregnancy Outcomes in DiEthylStilbestrol-exposed Offspring

Pregnancy outcomes in DES-exposed women are worse than those in unexposed women

2000 Study Abstract

Continued follow-up of pregnancy outcomes in diethylstilbestrol-exposed offspring
Pregnancy outcomes in DES Daugters are worse than those in unexposed women

Objective
To evaluate long-term pregnancy experiences of women exposed to diethylstilbestrol (DES) in utero compared with unexposed women.

Methods
This study was based on diethylstilbestrol-exposed daughters, the National Collaborative Diethylstylbistrol Adenosis cohort and the Chicago cohort, and their respective nonexposed comparison groups. Subjects who could be traced were sent a detailed questionnaire in 1994 that contained questions on health history, including information on pregnancies and their outcomes. We reviewed 3373 questionnaires from exposed daughters and 1036 questionnaires from unexposed women.

Results
The response rate was 88% among exposed and unexposed women. Diethylstilbestrol-exposed women were less likely than unexposed women to have had full-term live births and more likely to have had premature births, spontaneous pregnancy losses, or ectopic pregnancies. Full-term infants were delivered in the first pregnancies of 84.5% of unexposed women compared with 64. 1% of exposed women identified by record review (relative risk [RR] 0.76, confidence interval [CI] 0.72, 0.80). Preterm delivery of first births occurred in 4.1% of unexposed compared with 11.5% of exposed women, and ectopic pregnancies in 0.77% of unexposed compared with 4.2% of exposed women. Spontaneous abortion was reported in 19.2% of DES-exposed women compared with 10.3% in control women (RR 2.00, CI 1.54, 2.60). According to complete pregnancy histories (many women had more than one pregnancy), preterm births were more common in DES-exposed women (19.4% exposed versus 7.5% unexposed (RR 2.93 CI 2.23, 3.86). Second-trimester spontaneous pregnancy losses were more common in DES-exposed women (6.3% versus 1.6%; RR 4.25, CI 2.36, 7.66). More first-trimester spontaneous abortions occurred in DES-exposed women than in controls (RR 1.31, CI 1.13, 1.53), and DES-exposed women had at least one ectopic pregnancy more often than unexposed women (RR 3.84, CI 2.26, 6.54).

Conclusion
Pregnancy outcomes in DES-exposed women were worse than those in unexposed women.

Sources: Continued follow-up of pregnancy outcomes in diethylstilbestrol-exposed offspringNCBI, Dr Herbst A, Oct 2000 – full PDF.

Sadly for many DES daughters having their own children is not possible! Many of us who have experienced miscarriages, want to have kids but are struggling or unable to… Read more about DES pregnancy risks – our posts tagged pregnancy.

More DES DiEthylStilbestrol Resources

Shift Work might affect Women’s Menstruation and Fertility

Women who only worked at night also had higher odds for miscarriage

Shift Work Might Affect Women's Periods, Fertility: Study
The stress of fluctuating work hours might also play a role

Shift work may raise a woman’s risk of menstrual and fertility problems, and steady night shifts may boost the odds for miscarriage, a new study suggests.

British researchers analyzed all studies on shift work and reproduction published between 1969 and 2013. The data from more than 119,000 women revealed that those working shifts (alternating shifts, evenings and nights) had a 33% higher risk of menstrual problems and an 80% higher risk of fertility problems than those who worked regular hours.

Finding Hope after Miscarriage…

A pregnancy loss is happening to 25% of all known pregnancies

Finding Hope After Miscarriage
Personal Stories

One year I was pregnant four times.
I was 38 and newly married. I got pregnant the first time in January.
A few weeks later, I miscarried. For every season of that year, I have a photo of me holding a pregnancy test with two pink lines marking positive. By summer my smile is tentative. Each pregnancy followed its own, idiosyncratic course. One ended gently, just days after a home test turned positive. Another hung on 10 weeks, the embryo’s heart stopping after we’d seen it pulsing during two previous ultrasounds. Another pregnancy my doctor tried to save by prescribing progesterone.
That only caused the little bundle of cells to cling to me too tenaciously, long after it stopped growing
…. ”

Continue reading Finding Hope After Miscarriage
by Kendra Hurley, Jan 10, 2013

Sadly for many DES daughters having their own children is not possible! Many of us who have experienced miscarriages, want to have kids but are struggling or unable to…

Our Guardian Angel Senator Lisa Boscola

Pregnancy Drug Guardian Angel

Pregnancy drug guardian angel
Pennsylvania State Senator Lisa Boscola

Pennsylvania Senator Lisa Boscola getting State help to research effects of  DES.
Sen. Boscola suspects the pregnancy drug her mother took played a role in her four miscarriages.
$250,000 in budget planned to hunt for answers.

Read Pregnancy Drug Guardian Angel
by  Yung Kim, May 19, 2000.

More DES DiEthylStilbestrol Resources

After Miscarrying I never got the Pregnant Glow back

We need to change the way miscarriage and pregnancy loss is handled outside of the medical community

After miscarrying I never got the Pregnant Glow back
Personal Stories

There is a fantasy surrounding pregnancy portraying it as a blissful state when women glow with health and the miracle of life. It is a time when most women feel pride in their bodies, more forgiving of their imperfections, and awestruck by their body’s capabilities. Yet, when a woman has experienced miscarriage and/or infertility, a pregnancy can be filled with fear and anxiety.

Continue reading After miscarrying I never got the Pregnant Glow back, by Erica Berman, PhD, HuffPost Living, November 2012

Sadly for many DES daughters having their own children is not possible! Many of us who have experienced miscarriages, want to have kids but are struggling or unable to…

Doctors must be sensitive to Women at Risk of Miscarriage and Ectopic Pregnancy, NICE report says

Ectopic pregnancy and miscarriage: diagnosis and initial management

Doctors must be sensitive to Women at Risk of Miscarriage and Ectopic Pregnancy, NICE report says
Doctors must be more sympathetic to pregnant women in danger of losing their babies, according to NICE

The National Institute for Health and Clinical Excellence believes doctors do not give enough information or support to women at risk of miscarriages or ectopic pregnancies. NICE says that the NHS should consider setting up dedicated services for pregnant women who may have an ectopic pregnancy or who experience pain or bleeding in their first trimester. This is according to their December 2012 guideline on the diagnosis and management of ectopic pregnancy and miscarriage in early pregnancy.

More information:

Sadly for many DES daughters having their own children is not possible! Many of us who have experienced miscarriages, want to have kids but are struggling or unable to…

No Matter when it happens, Loss of a Pregnancy can be devastating

We need to change the way miscarriage and pregnancy loss is handled outside of the medical community

No Matter when it happens, Loss of a Pregnancy can be devastating
Personal Stories

It is an event in my life that I will never forget. I woke up one morning and after four weeks of nausea, fatigue and strange cravings, I felt “normal,” which seemed wrong. Everyone reassured me there was no reason to worry. I’d seen a strong heartbeat at a six-week ultrasound, I’d had no cramping or bleeding, and it is normal for pregnancy symptoms to fluctuate. But I just knew in my gut something was wrong.”

Continue reading No Matter When it Happens,
Loss of a Pregnancy Can Be Devastating
by Erica Berman, PhD, HuffPost Healthy Living, July 2012

Sadly for many DES daughters having their own children is not possible! Many of us who have experienced miscarriages, want to have kids but are struggling or unable to…

Pregnancy or not : what is and is NOT appropriate to say to a Woman about her Body and/or Fertility

12 Things You Should Never Ask a Woman
Never ask any woman if she is pregnant…

Any woman struggling with infertility or who has experienced a miscarriage has probably had to deal with her fair share of stupid comments and reactions from others.

Erica Berman, PhD, thought she would put together a little “guide” regarding what is and is not appropriate to say to a woman about her body and/or fertility…

Read 12 Things You Should Never Ask a Woman
HuffPost Women, October 2012

Sadly for many DES daughters having their own children is not possible! Many of us who have experienced miscarriages, want to have kids but are struggling or unable to…

My IVF Treatments: losing our Baby, the Pain of a Miscarriage

We need to change the way miscarriage and pregnancy loss is handled outside of the medical community

Losing our baby: The pain of a miscarriage
Personal Stories

My name is Grace. I’ve been reading the personal stories on this site since last year, and when my partner Cara and I started IUI treatments with donor sperm 10 months ago, I thought I’d be writing in to share the news of my pregnancy. Sadly, the story that I am sharing is a different one. ”

Continue reading Losing our baby: The pain of a miscarriage
on MyFertilityChoices.com, Personal Stories – also on Twitter

Sadly for many DES daughters having their own children is not possible! Many of us who have experienced miscarriages, want to have kids but are struggling or unable to…