Green is the New Pink

Stop Putting Cancer-causing Chemicals on Your Face

Many beauty ingredients have been linked to breast cancer.

Sources

Endocrine Disruptors

Personal Care Products

Are your PCPs really Safe?

Sources

Endocrine Disruptors

Perturbateurs endocriniens : tous intoxiqués?

Les nouveaux poisons de notre quotidien

Enquête de santé, Allo Docteurs France 5, 01/02/2017.

Un documentaire / débat diffusé le 31 janvier 2017 sur France 5.

Documentaire

Débat

Les perturbateurs endocriniens, substances chimiques, sont présentes dans de nombreux objets de consommation courante : plastiques, résidus de pesticides sur les fruits et légumes, OGM, cosmétiques, lunettes, semelles de chaussures… Ils interagissent avec le système hormonal et seraient responsables de l’augmentation de certains cancers, selon des associations impliquées dans les problèmes de santé liés à l’environnement.

Sur le même sujet

Le Distilbène, Perturbateur Endocrinien

Toxic Chemicals are Harmless at Low Dose

EDCs Myth vs. Fact, The Hormone Health Network Infographic

Endocrine disrupting chemicals (EDCs) are a serious risk in modern society. These chemical compounds can interfere with the way the body’s hormones work, and they are associated with an array of health issues. Worse, they are almost everywhere: in consumer products such as pesticides, plastics, food storage materials, personal care products, clothing and more, and they also are used in electronics and agriculture.

Unfortunately, a number of myths about EDCs being safe have been perpetuated because of a lack of understanding about the realities of these chemicals and their effects on the body.

Some people claim EDCs represent no risk at all, and that all of the warnings about them are scare tactics and exaggerated. Others present myths as facts just so product sales will not be hurt. To take or maintain control of your hormone health, you must understand EDC facts so you can make wise decisions regarding your health.

Sources

Endocrine Disruptors

Occurrence and migration of a wide range EDCs from intact surfaces of baby teethers

Migration of Parabens, Bisphenols, Benzophenone-Type UV Filters, Triclosan, and Triclocarban from Teethers and Its Implications for Infant Exposure

Certain teething products often used for young children and babies may contain bisphenols, parabens, triclosan and harmful chemicals – including those marked BPA-free – all materials that are used in personal care products and plastics that have been banned or restricted by the EU and US governments.

Abstract

Parabens (p-hydroxybenzoic acid esters), bisphenols, benzophenone-type UV filters, triclosan, and triclocarban are used in a variety of consumer products, including baby teethers. Nevertheless, the exposure of infants to these chemicals through the use of teethers is still unknown.

In this study, 59 teethers, encompassing three types, namely solid plastic, gel-filled, and water-filled (most labeled “bisphenol A-free”), were collected from the U.S. market and analyzed for 26 potential endocrine-disrupting chemicals (EDCs) from intact surfaces through migration/leaching tests performed with Milli-Q water and methanol.

Migration of Parabens, Bisphenols, Benzophenone-Type UV Filters, Triclosan, and Triclocarban from Teethers and Its Implications for Infant Exposure Environmental Science and Technology, DOI: 10.1021/acs.est.6b04128, December 7, 2016.

baby booty by pinprick.

The total amount of the sum of six parent parabens (Σ6 Parabens) leached from teethers ranged from 2.0 to 1990 ng, whereas that of their four transformation products (Σ4 Parabens) ranged from 0.47 to 839 ng. The total amount of the sum of nine bisphenols (Σ9 bisphenols) and 5 benzophenones (Σ5 benzophenones) leached from teethers ranged from 1.93 to 213 ng and 0.59 to 297 ng, respectively. Triclosan and triclocarban were found in the extracts of teethers at approximately 10-fold less amounts than were bisphenols and benzophenones.

Based on the amount leached into Milli-Q water, daily intake of these chemicals was estimated from the use of teethers by infants at 12 months of age. This is the first study to document the occurrence and migration of a wide range EDCs from intact surfaces of baby teethers.

Cosmetics use and age at menopause: is there a connection?

Endocrine disrupting chemicals and reproductive disorders

Abstract

Cosmetics contain a vast number of chemicals, most of which are not under the regulatory purview of the Food and Drug Administration.

Only a few of these chemicals have been evaluated for potential deleterious health impact: parabens, phthalates, polycyclic aromatic hydrocarbons, and siloxanes.

A review of the ingredients in the best-selling and top-rated products of the top beauty brands in the world, as well as a review of highlighted chemicals by nonprofit environmental organizations, reveals 11 chemicals and chemical families of concern: butylated hydroxyanisole/butylated hydroxytoluene, coal tar dyes, diethanolamine, formaldehyde-releasing preservatives, parabens, phthalates, 1,4-dioxane, polycyclic aromatic hydrocarbons, siloxanes, talc/asbestos, and triclosan.

Cosmetics use and age at menopause: is there a connection?, Fertility and Sterility, Volume 106, Issue 4, Pages Pages 978–990, September 15, 2016.

“Cosmetics” image akiraohgaki.

Age at menopause can be affected by a variety of mechanisms, including endocrine disruption, failure of DNA repair, oxidative stress, shortened telomere length, and ovarian toxicity.

There is a lack of available studies to make a conclusion regarding cosmetics use and age at menopause. What little data there are suggest that future studies are warranted. Women with chronic and consistent use of cosmetics across their lifespan may be a population of concern.

More research is required to better elucidate the relationship and time windows of vulnerability and the effects of mixtures and combinations of products on ovarian health.

Protecting you and your baby in pregnancy

A guide to avoiding hazardous chemicals in everyday products

EDCs: reduce your risk, there are things you can do.

There is growing scientific concern that early life exposures to certain harmful chemicals in our environment may lead to illnesses later in life.

This guide provides some information on what to look out for and what to avoid, both during pregnancy and as your family grows.

EDCs : are you being exposed?

Identify and avoid harmful chemicals in everyday products

EDCs: reduce your risk, there are things you can do.

Not all chemicals are harmful, but some are capable of causing cancer (carcinogens) and others can interfere with normal hormone functions; these are known as endocrine disrupting chemicals or EDCs. Some EDCs mimic the female hormone, oestrogen, which is a known risk factor for breast cancer.

Certain chemicals in lotions, soaps and makeup additives linked to preterm births, smaller babies

Association of birth outcomes with fetal exposure to parabens, triclosan and triclocarban

Soap, makeup additives linked to preterm births, smaller babies, environmental healthnews, May 11, 2016.

Pregnant women in Brooklyn with high levels of certain compounds used in makeup and soaps were more likely to have preterm births and babies that weighed less.

The study, available online 11 March 2016, provides the first evidence that germ-killing and preservative chemicals used in cosmetics and soaps might impact newborns’ health. It also bolsters suspicions that chemicals in soaps and lotions disrupt people’s endocrine systems, which are crucial for reproduction and babies’ development. ”

Abstract

Association of birth outcomes with fetal exposure to parabens, triclosan and triclocarban in an immigrant population in Brooklyn, New York, science direct, 11 March 2016.
Image Michael Korbel.

Background
Prior studies suggest associations between fetal exposure to antimicrobial and paraben compounds with adverse reproductive outcomes, mainly in animal models. We have previously reported elevated levels of these compounds for a cohort of mothers and neonates.

Objective
We examined the relationship between human exposure to parabens and antimicrobial compounds and birth outcomes including birth weight, body length and head size, and gestational age at birth.

Methods
Maternal third trimester urinary and umbilical cord blood plasma concentrations of methylparaben (MePB), ethylparaben (EtPB), propylparaben (PrPB), butylparaben (BuPB), benzylparaben (BePB), triclosan (2,4,4′-trichloro-2′-hydroxydiphenyl ether or TCS) and triclocarban (1-(4-chlorophenyl)-3-(3,4-dichlorophenyl) urea or TCC), were measured in 185 mothers and 34 paired singleton neonates in New York, 2007–2009.

Results
In regression models adjusting for confounders, adverse exposure-outcome associations observed included increased odds of PTB (BuPB), decreased gestational age at birth (BuPB and TCC) and birth weight (BuPB), decreased body length (PrPB) and protective effects on PTB (BePB) and LBW (3′-Cl-TCC) (p < 0.05). No associations were observed for MePB, EtPB, or TCS.

Conclusions
This study provides the first evidence of associations between antimicrobials and potential adverse birth outcomes in neonates. Findings are consistent with animal data suggesting endocrine-disrupting potential resulting in developmental and reproductive toxicity.

Parabens in Personal Products and Breast Cancer

Lotion ingredient paraben may be more potent carcinogen than thought

image of parabens-in-personal-products
A group of chemicals commonly used in cosmetics and other personal-care products may stimulate the growth of breast cancer cells at doses much lower than previously thought. Parabens are a type of chemical preservative, and are found in a wide array of consumer products, including shampoos, body lotions and sunscreens

2015 Study Abstract

Background:
Xenoestrogens are synthetic compounds that mimic endogenous estrogens by binding to and activating estrogen receptors. Exposure to estrogens and some xenoestrogens has been associated with cell proliferation and increased risk of breast cancer. Despite evidence of estrogenicity, parabens are among the most widely used xenoestrogens in cosmetics and personal care products, and generally considered safe. However, previous cell based studies with parabens do not take into account the signaling cross-talk between estrogen receptor (ERα) and the human epidermal growth factor receptor (HER) family.

Objectives:
We investigated the hypothesis that the potency of parabens can be increased with HER ligands, such as heregulin (HRG).

Methods:
The effects of HER ligands on paraben activation of c-Myc expression and cell proliferation were determined by real-time PCR, western blots, flow cytometry and chromatin immunoprecipitation assays in ERα- and HER2-positive human BT-474 breast cancer cells.

Results:
Butylparaben (BP) and HRG produced a synergistic increase in c-Myc mRNA and protein levels in BT-474 cells. Estrogen receptor antagonists blocked the synergistic increase in c-Myc protein levels. The combination of BP and HRG also stimulated proliferation of BT-474 cells compared to BP alone. HRG decreased the dose required for BP-mediated stimulation of c-Myc mRNA expression and cell proliferation. HRG caused the phosphorylation of serine 167 in ERα. BP and HRG produced a synergistic increase in ERα recruitment to the c-Myc gene.

Conclusion:
Our studies demonstrate that HER ligands enhance the potency of BP to stimulate oncogene expression and breast cancer cell proliferation in vitro via ERα, suggesting that parabens might be active at exposure levels not previously considered toxicologically relevant from studies testing their effects in isolation.

Sources and more information
  • Parabens and Human Epidermal Growth Factor Receptor Ligands Cross-Talk in Breast Cancer Cells, Environ Health Perspect; DOI:10.1289/ehp.1409200, 27 October 2015.
  • Lotion ingredient paraben may be more potent carcinogen than thought, berkeley.edu, OCTOBER 27, 2015.
  • Chemicals in Personal Products May Stimulate Cancer More Than Thought, livescience, October 27, 2015