All Trials Registered, All Results Reported, why the Campaign Matters

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All Trials Registered, All Results Reported, why the #AllTrials Campaign Matters
Join and sign the #AllTrials petition for all trials registered and all results reported

Around half of all clinical trials have not been published; some trials have not even been registered. If action is not taken urgently, information on what was done and what was found in trials could be lost forever, leading to bad treatment decisions, missed opportunities for good medicine, and trials being repeated unnecessarily.

Historical Review of the DES Tragedy, glaring Example of what NOT to do in Medicine…

The Diethylstilbestrol tragedy thorough historical review

Problems in Research: Regulations—The Diethylstilbestrol Tragedy
The diethylstilbestrol tragedy: a failure of oversight or poor science?

For a thorough historical review of the DES tragedy take a moment and read this lengthy call for tighter FDA regulation of the drug industry. The DES story makes a compelling case!

DES Action USA commented: ” Thank you for this call for stronger government regulation of pharmaceuticals. The DES tragedy makes a compelling case and you tell the story well. Adding insult to injury, it isn’t correct to say that in 1971 the FDA banned DES for most uses. Sadly, DES was only ‘contraindicated’ so it was well into the 1970s before doctors stopped prescribing DES to pregnant women! Either they didn’t get the word, or they felt they knew better than government regulators. Many doctors now dismiss DES exposure as ‘not a problem anymore’ but millions of us were exposed before birth and live with the health problems it caused. We fervently wish similar tragedies wouldn’t happen again – but sadly, the DES lessons learned are being ignored.

Read Problems in Research: Regulations—The Diethylstilbestrol Tragedymedicalbag, April 12, 2013.

More DES DiEthylStilbestrol Resources

Fertility Clinic advertising on the Web: more Concerns about direct-to-Consumer Pharmaceutical Ads

What’s wrong with Fertility Clinics and Online Advertising

What’s Wrong With Fertility Clinics and Online AdvertisingDid you know the United States and New Zealand are the only nations that permit direct-to-consumer pharmaceutical ads?

Sadly, these clinic sites too often try to influence consumers with misleading information about their ability to create successful pregnancies.

DES Action USA commentd: ” Infertility plagued many DES Daughters and now there’s growing concern it may also be an issue for DES Granddaughters. Here’s fair warning about fertility clinic cute baby photos and glowing stats. Regulators are asleep at the switch on this type of advertising “.

Read What’s wrong with Fertility Clinics and Online Advertising.

Sources Direct-to-Consumer: Fertility Clinic Advertising on the Web.

Combined Net Profits for Top Global Pharmaceutical Companies, 2003-2012

Big Pharma Pockets $711 Billion in Profits by Robbing Seniors, Taxpayers

Big Pharma Pockets $711 Billion in Profits by Robbing Seniors, TaxpayersThe eleven largest global drug companies made an astonishing $711 billion in profits over the ten years ending in 2012.

In his post, Ethan Rome says: ” There are two reasons why it matters that the drug industry is booking eye-popping profits. First, American consumers and taxpayers are footing the bill, and second, we could do something about it. ‘

Read Big Pharma Pockets $711 Billion in Profits by Robbing Seniors, Taxpayers, huffingtonpost, 04/08/2013.

Why Researchers MUST publish ALL Results of Clinical Trials

Make all medical research results public

Make all research results publicA new campaign All trials registered, all results reported  – supported by the Medical Research Council  (publicly funded organisation in the UK dedicated to improving human health) – calls for the results of all clinical trials to be made public.
Sir Iain Chalmers, Coordinator of the James Lind Initiative, has strong words on researchers who hide trial results and ends his post by saying: “ If action is not taken urgently by research funders and regulators, information on what was done and what was found in trials could be lost forever, leading to bad treatment decisions, unnecessary repetition of trials, and missed opportunities for good medical practice. ”

Read Make all research results public, insight, 4 April 2013.
#AllTrials website and donation site.

Watch the Seattle Book Discussion about Bad Pharma

How Drug Companies Mislead Doctors and Harm Patients

Watch the Seattle Book Discussion about Bad Pharma, an 86 min Video with @BenGoldacreLast February 18th, 2013, at Town Hall Seattle, Dr. Ben Goldacre talked about his book, Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients, in which he discusses the influence of the pharmaceutical industry on the global healthcare system and argues that pharmaceutical companies hide negative studies and use questionable testing and intensive lobbying to get what they want, regardless of whether the drugs they produce are good for patients. Watch the video  (1 hour, 26 minutes) .

More about Ben Goldacre

DES Videos in English – Diethylstilboestrol YT video channel.

The Association of the British Pharmaceutical Industry revealing how much they paid UK Doctors

Drug companies pay doctors £40m for travel and expenses

Drug companies pay doctors £40m for travel and expensesDrug companies are paying an estimated £40m a year to British doctors in service fees, flights, hotel and other travel expenses, according to the trade body that represents pharmaceutical companies.

Doctors have always denied that taking drug company money influences their judgement in any way about a medicine, but suspicions have lingered.

Read Drug companies pay doctors £40m for travel and expenses
by Sarah Boseley, The Guardian, april 2013.

Big Pharma and Doctors, or the Influence of the Pharmaceutical Industry

Why do so many doctors still think they are invincible to Big Pharma’s influence?

Doctors Are Under the Influence of Pharma DrugsThe bottom line for any for-profit company is to sell their product, and since the pharmaceutical industry can’t sell drugs directly to patients, they convince doctors to prescribe them.
The more a doctor sees or hears the name of a drug, whether through drug reps, brochures or seeing the name on stationery, the more likely the drug is to be prescribed
. ”

Read Doctors Are Under the Influence of Pharma Drugs by Ritika Goel, 04/02/2013.

Pay-to-delay Deals keep Consumer Prices artificially high to protect Drug Patent-Holders’ Profits

Pay-to-delay deals costly for the general public

How ‘Pay for Delay’ Keeps Us Paying More for Prescription Drugs” … When a company’s patent on a brand-name drug expires, other companies are free to make generic versions of the same drug… Often times, there are legal disputes between brand-name drug manufacturers and generic-drug companies. It’s increasingly common for this litigation to end with out-of-court settlements in which patentholders pay potential competitors to delay the introduction of generics.
That’s pay-to-delay
… ”

Read PD Editorial: Pay-to-delay deals costly for consumers.

Read How ‘Pay for Delay’ Keeps Us Paying More for Prescription Drugs.

What Doctors don’t know about the Drugs they prescribe…

How Drug Companies mislead Doctors and harm Patients

When a new drug gets tested, the results of the trials should be published for the rest of the medical world — except much of the time, negative or inconclusive findings go unreported, leaving doctors and researchers in the dark. In this impassioned talk, Ben Goldacre explains why these unreported instances of negative data are especially misleading and dangerous.

More about Ben Goldacre

DES Videos in English – Diethylstilboestrol YouTube video channel.