Carol Devine is a DES Daughter and founder and coordinator of the Sydney based group, DES Action Australia-NSW, which formed in 1995
Carol Devine is a DES Daughter and founder and coordinator of the Sydney based group, DES Action Australia-NSW, which formed in 1995. The group has been contacted by thousands of people across Australia affected by the anti-miscarriage drug DES (diethylstilboestrol or “stilboestrol”). In 2008, Carol received judges highly commended in the Soapbox Category by Fellowship of Australian Writers – Qld for her article titled “Voices of Thousands Ring”.
Many people, including those unaffected by the DES drug have been moved in some way by this written work as it sheds light on the Australian experience of DES exposure.
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EDCs like DES impact human health in ways we are only just beginning to understand
“Yes, there are third generation effects from this drug. Researchers are just beginning to untangle the third generation effects. In women, menstrual irregularities appear more common as do the various forms of cancer, but the data are unclear. In men, hypospodias may be more frequent, but again the data are mixed.”
I kept asking for my baby and they kept telling me “no”
” C Cole is one of an unknown number of mostly young, unmarried women in NSW between the 1950s and 1970s whose children were taken from them in what is commonly referred to as ”forced adoption”. ”
” Ms Cole was given a range of drugs against her will during her stay in hospital, including mind-altering barbiturates and Stilboestrol, to dry her milk. She was never told she had a right to revoke her consent to adoption in the weeks after the birth. ”
High-fat or ethinyl-oestradiol intake during pregnancy increases mammary cancer risk in several generations of offspring
” A study by researchers from Georgetown Lombardi Comprehensive Cancer Center and Virginia Tech shows that exposure to diets high in fat or a large amount of estrogen during pregnancy can heighten the risk of breast cancer for numerous subsequent generations of female offspring, including daughters, granddaughters and great-granddaughters. ”
Maternal exposures to environmental factors during pregnancy influence the risk of many chronic adult-onset diseases in the offspring. Here we investigate whether feeding pregnant rats a high-fat (HF)- or ethinyl-oestradiol (EE2)-supplemented diet affects carcinogen-induced mammary cancer risk in daughters, granddaughters and great-granddaughters. We show that mammary tumourigenesis is higher in daughters and granddaughters of HF rat dams and in daughters and great-granddaughters of EE2 rat dams. Outcross experiments suggest that the increase in mammary cancer risk is transmitted to HF granddaughters equally through the female or male germ lines, but it is only transmitted to EE2 granddaughters through the female germ line. The effects of maternal EE2 exposure on offspring’s mammary cancer risk are associated with changes in the DNA methylation machinery and methylation patterns in mammary tissue of all three EE2 generations. We conclude that dietary and oestrogenic exposures in pregnancy increase breast cancer risk in multiple generations of offspring, possibly through epigenetic means.
Read Pregnancy Exposure Increases Breast Cancer Inheritance in Offspring, redorbit, September 2012..
High-fat or ethinyl-oestradiol intake during pregnancy increases mammary cancer risk in several generations of offspring, nature, 11 September 2012.
Pregnancy exposures determine risk of breast cancer in multiple generations of offspring,eurekalert, 11-SEP-2012.