Glyphosate-exposed shows a change in intestinal flora, study

The Ramazzini Institute 13-week pilot study on glyphosate and Roundup administered at human-equivalent dose to Sprague Dawley rats: effects on the microbiome

A study published on May 2018 by an international consortium of researchers, shows a change in intestinal flora in exposed animals, compared to control group. Image credit telegraph.

2019 Study Abstract

Background
Glyphosate-based herbicides (GBHs) are broad-spectrum herbicides that act on the shikimate pathway in bacteria, fungi, and plants. The possible effects of GBHs on human health are the subject of an intense public debate for both its potential carcinogenic and non-carcinogenic effects, including its effects on microbiome. The present pilot study examines whether exposure to GBHs at doses of glyphosate considered to be “safe” (the US Acceptable Daily Intake – ADI – of 1.75 mg/kg bw/day), starting from in utero, may modify the composition of gut microbiome in Sprague Dawley (SD) rats.

Methods
Glyphosate alone and Roundup, a commercial brand of GBHs, were administered in drinking water at doses comparable to the US glyphosate ADI (1.75 mg/kg bw/day) to F0 dams starting from the gestational day (GD) 6 up to postnatal day (PND) 125. Animal feces were collected at multiple time points from both F0 dams and F1 pups. The gut microbiota of 433 fecal samples were profiled at V3-V4 region of 16S ribosomal RNA gene and further taxonomically assigned and assessed for diversity analysis. We tested the effect of exposure on overall microbiome diversity using PERMANOVA and on individual taxa by LEfSe analysis.

Results
Microbiome profiling revealed that low-dose exposure to Roundup and glyphosate resulted in significant and distinctive changes in overall bacterial composition in F1 pups only. Specifically, at PND31, corresponding to pre-pubertal age in humans, relative abundance for Bacteriodetes (Prevotella) was increased while the Firmicutes (Lactobacillus) was reduced in both Roundup and glyphosate exposed F1 pups compared to controls.

Conclusions
This study provides initial evidence that exposures to commonly used GBHs, at doses considered safe, are capable of modifying the gut microbiota in early development, particularly before the onset of puberty. These findings warrant future studies on potential health effects of GBHs in early development such as childhood.

Glyphosate suspected to be an endocrine disruptor

The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

A new study, published on March 12 2019 by an international consortium of researchers, adds a new controversy about this product already suspected of being genotoxic or carcinogenic. Image credit republic.ru.

2019 Study Abstract

Background
Glyphosate-based herbicides (GBHs) are broad-spectrum herbicides that act on the shikimate pathway in bacteria, fungi, and plants. The possible effects of GBHs on human health are the subject of an intense public debate for both its potential carcinogenic and non-carcinogenic effects, including potential effects on the endocrine system The present pilot study examine whether exposure to GBHs at the dose of glyphosate considered to be “safe” (the US Acceptable Daily Intake – ADI – of 1.75 mg/kg bw/day), starting from in utero life, affect the development and endocrine system across different life stages in Sprague Dawley (SD) rats.

Methods
Glyphosate alone and Roundup Bioflow, a commercial brand of GBHs, were administered in drinking water at 1.75 mg/kg bw/day to F0 dams starting from the gestational day (GD) 6 (in utero) up to postnatal day (PND) 120. After weaning, offspring were randomly distributed in two cohorts: 8 M + 8F/group animals belonging to the 6-week cohort were sacrificed after puberty at PND 73 ± 2; 10 M + 10F/group animals belonging to the 13-week cohort were sacrificed at adulthood at PND 125 ± 2. Effects of glyphosate or Roundup exposure were assessed on developmental landmarks and sexual characteristics of pups.

Results
In pups, anogenital distance (AGD) at PND 4 was statistically significantly increased both in Roundup-treated males and females and in glyphosate-treated males. Age at first estrous (FE) was significantly delayed in the Roundup-exposed group and serum testosterone concentration significantly increased in Roundup-treated female offspring from the 13-week cohort compared to control animals. A statistically significant increase in plasma TSH concentration was observed in glyphosate-treated males compared with control animals as well as a statistically significant decrease in DHT and increase in BDNF in Roundup-treated males. Hormonal status imbalances were more pronounced in Roundup-treated rats after prolonged exposure.

Conclusions
The present pilot study demonstrate that GBHs exposure, from prenatal period to adulthood, induced endocrine effects and altered reproductive developmental parameters in male and female SD rats. In particular, it was associated with androgen-like effects, including a statistically significant increase of AGDs in both males and females, delay of FE and increased testosterone in female.

Paul François, un agriculteur contre Monsanto

Interview Brut, Février 2019

Paul François avait réussi à faire condamner Monsanto, puis la Cour de cassation a cassé le jugement.

Aujourd’hui, Paul François entame son 4ème procès contre le géant des OGM et continue de se battre pour une agriculture responsable et l’arrêt de l’utilisation du glyphosate. Il raconte.

Élise Lucet sur le glyphosate

Interview Brut, Janvier 2019

Envoyé spécial a consacré une soirée spéciale au glyphosate le jeudi 17 janvier à 21h sur France 2

Atteint d’un cancer incurable, l’Américain Dewayne Johnson a attaqué en justice Monsanto. C’est le premier au monde à avoir gagné un procès contre le géant américain. Elise Lucet raconte toute l’histoire pour Brut.

Pas de glyphosate dans ma Teucha !!!

Les tampons et serviettes hygiéniques contiennent toujours des résidus chimiques

De nouvelles analyses mettent en évidence la présence récurrente de pesticides et de phtalates dans les protections périodiques féminines malgré les dernières recommandations officielles.

  • Le Billet de Sophia Aram, franceinter, 25 février 2019.
  • Tampons et serviettes : connaître la composition, c’est coton ! 60millions-mag, 2019/02/21.
  • Tampons et protections féminines : un rapport ni alarmant ni rassurant, 60millions-mag, 2018/07/20.
  • Tampons et protections féminines : une réglementation s’impose ! 60millions-mag, 2016/02/23.

Exposure to Glyphosate-Based Herbicides and Risk for Non-Hodgkin Lymphoma

A Meta-Analysis and Supporting Evidence, Mutation Research/Reviews, February 2019

Abstract

Glyphosate is the most widely used broad-spectrum systemic herbicide in the world. Recent evaluations of the carcinogenic potential of glyphosate-based herbicides (GBHs) by various regional, national, and international agencies have engendered controversy.

We investigated whether there was an association between high cumulative exposures to GBHs and increased risk of non-Hodgkin lymphoma (NHL) in humans. We conducted a new meta-analysis that included the most recent update of the Agricultural Health Study (AHS) cohort published in 2018 along with five case-control studies.

Using the highest exposure groups when available in each study, we report the overall meta-relative risk (meta-RR) of NHL in GBH-exposed individuals was increased by 41% (meta-RR = 1.41, 95% CI, confidence interval: 1.13–1.75). For comparison, we also performed a secondary meta-analysis using high-exposure groups with the earlier AHS (2005), and we determined a meta-RR for NHL of 1.45 (95% CI: 1.11–1.91), which was higher than the meta-RRs reported previously. Multiple sensitivity tests conducted to assess the validity of our findings did not reveal meaningful differences from our primary estimated meta-RR. To contextualize our findings of an increased NHL risk in individuals with high GBH exposure, we reviewed available animal and mechanistic studies, which provided supporting evidence for the carcinogenic potential of GBH. We documented further support from studies of malignant lymphoma incidence in mice treated with pure glyphosate, as well as potential links between GBH exposure and immunosuppression, endocrine disruption, and genetic alterations that are commonly associated with NHL.

Overall, in accordance with evidence from experimental animal and mechanistic studies, our current meta-analysis of human epidemiological studies suggests a compelling link between exposures to GBHs and increased risk for NHL.

 

Reference. Image credit gmwatch.

La désinformation organisée par les firmes doit cesser, dit Maître Lafforgue

Comment Monsanto assure sa défense et nie en bloc toute responsabilité devant la justice

“Les médecins qui mettent en doute les troubles de M. François ne sont pas des experts judiciaires, ce sont des consultants payés par Monsanto.”

dénonce Maître François Lafforgue, l’avocat de Paul François.

La Cour d’appel de Lyon doit se prononcer sur la responsabilité présumée de Monsanto dans les troubles médicaux de Paul François, céréalier charentais. Depuis douze ans, il accuse la firme d’avoir exposé les utilisateurs du Lasso, puissant herbicide, à de graves dangers.

France 3 Auvergne-Rhône-Alpes, un reportage de Yaëlle Marie et Laure Crozat publié sur YouTube le 6 février 2019.

Référence : Lyon : Comment Monsanto assure sa défense et nie en bloc toute responsabilité devant la justice ?

(Bayer), Monsanto, et la fabrique du doute

Une firme, qui ne s’estime ni responsable ni coupable, et fait appel de ses condamnations ?

Les “Monsanto Papers” ont révélé comment le géant américain a fait rédiger en secret, par ses propres scientifiques, des études pour prouver que le glyphosate n’était pas dangereux.

Le glyphosate, l’herbicide le plus vendu au monde, a fait couler beaucoup d’encre en 2017 et 2018.

Envoyé spécial, un reportage de Tristan Waleckx, Guillaume Beaufils et Mikael Bozo publié sur YouTube le 22 janvier 2019.

Référence : “Envoyé spécial”. Glyphosate : comment s’en sortir ?.

The corruption of science by the industry (agrochemical)

The Monsanto Papers: Poisoning the scientific well

Monsanto flooded scientific journals with ghostwritten articles and interfered in the scientific process in order to defend its glyphosate herbicides

GMWatch reports, 14 August 2018.

The research article The Monsanto Papers: Poisoning the scientific well is a useful peer-reviewed source detailing Monsanto’s – corporate science – deceptive activities aimed at defending glyphosate herbicide, as revealed in the company’s internal documents force-disclosed in US cancer litigation and obtained by US Right to Know in freedom of information requests.

What is it about?

Examination of de-classified Monsanto documents from litigation in order to expose the impact of the company’s efforts to influence the reporting of scientific studies related to the safety of the herbicide, glyphosate

Why is it important?

The use of third-party academics in the corporate defense of glyhphosate reveals that this practice extends beyond the corruption of medicine and persists in spite of efforts to enforce transparency in industry manipulation.

Abstract

OBJECTIVE
Examination of de-classified Monsanto documents from litigation in order to expose the impact of the company’s efforts to influence the reporting of scientific studies related to the safety of the herbicide, glyphosate.

METHODS
A set of 141 recently de-classified documents, made public during the course of pending toxic tort litigation, In Re Roundup Products Liability Litigation were examined.

RESULTS
The documents reveal Monsanto-sponsored ghostwriting of articles published in toxicology journals and the lay media, interference in the peer review process, behind-the-scenes influence on retraction and the creation of a so-called academic website as a front for the defense of Monsanto products.

CONCLUSION
The use of third-party academics in the corporate defense of glyhphosate reveals that this practice extends beyond the corruption of medicine and persists in spite of efforts to enforce transparency in industry manipulation.

Glyphosate found in popular breakfast products

Weed Killer in $289 Million Cancer Verdict Found in Oat Cereal and Granola Bars

No one wants a breakfast that is contaminated with weed killer. Well, according to independent laboratory tests commissioned by EWG, popular oat cereals, oatmeal, granola and snack bars come with a hefty dose of the weed-killing poison in Roundup.

Glyphosate, an herbicide linked to cancer by California state scientists and the World Health Organization, was found in all but two of 45 samples of products made with conventionally grown oats. Almost three-fourths of those samples had glyphosate levels higher than what EWG scientists consider protective of children’s health with an adequate margin of safety. About one-third of 16 samples made with organically grown oats also had glyphosate, all at levels well below EWG’s health benchmark.

More information

  • Breakfast With a Dose of Roundup? EWG’s Children’s Health Initiative, AUGUST 15, 2018.
  • The Roundup Chemical Found Responsible for Cancer Might Also Be in Your Cereal, motherjones, Aug. 15, 2018.
  • Report: Oatmeal, breakfast foods contain unsafe amounts of weed killer, eu.freep, Aug 17, 2018.