Diethylstilbestrol geschiedenis, nog geen historie

Stichting DES-aktie en informatiecentrum, Utrecht, 1991

Video published on 23 August 2016 by DES in Belgium.

DES (diëthylstilbestrol) is een kunstmatig vrouwelijk hormoon (oestrogeen). Het werd in Nederland voorgeschreven aan zwangere vrouwen in de periode tussen 1947 en 1976. Het middel zou miskramen moeten voorkomen. Dat deed het niet, maar het zorgde wel voor gezondheidsproblemen bij de dochters van deze vrouwen. Ook werd bekend dat DES schadelijke gevolgen kan hebben voor de moeders zelf, hun zonen en mogelijk zelfs kleinkinderen.

DES DiEthylStilbestrol Resources

Van Wondermiddel tot Nachtmerrie ; het DES Hormoon

Hier en nu (29-03-1985, NCRV)

Video published on 1 November 2016 by DiEthylStilbestrol DES.

Het actualiteiten programma Hier en Nu van de NCRV maakte in 1985 een reportage over de gevolgen van het DES-hormoon.

Het was een kleine pil, met grote gevolgen. Zestig jaar geleden schreven artsen massaal een middel voor dat een zwangerschap zonder problemen beloofde, het DES-hormoon. Het leek een wondermiddel. Maar later bleek het preparaat nutteloos en vooral ook heel schadelijk. Tot op de dag van vandaag ondervinden in Nederland alleen al 220.000 moeders en hun kinderen de wrange gevolgen; misvormde baarmoeders, problemen met vruchtbaarheid en baarmoederkanker. Al in 1971 bleek uit Amerikaans onderzoek hoe ernstig de gevolgen waren en onmiddellijk is datzelfde jaar gestopt met voorschrijven in de Verenigde Staten. In Nederland drongen de feiten vier jaar later door en werd het middel in 1975 verboden. Intussen werden langzaam de gevolgen zichtbaar bij dochters van moeders die DES hadden geslikt. En inmiddels is gebleken dat ook kleinkinderen afwijkingen vertonen. Een medicijndrama waarvan het einde voorlopig niet in zicht is.

DES DiEthylStilbestrol Resources

Stilbestrol Tab 1mg

Taipei Veterans General Hospital, Taiwan

image of des-stilbestrol-1mg
Taipei Veterans General Hospital, Taiwan.

DES was sold under many names including Distilbène®, Stilbetin®, Stilboestrol-Borne®, Benzestrol®, Chlorotrianisene®, Estrobene® and Estrosyn® to name just a few.

Many different companies manufactured and marketed this drug under more than 200 different brand names.

These Stilbestrol tablets are current Taipei-VGH drugs marketed by Taipei Veterans General Hospital.

DES Drugs Pictures
More DES DiEthylStilbestrol Resources

Apex Stilboestrol Tablets 1mg

DES Tablets, Veterinary Products, Male Dog Neutering

image of apex-stilboestrol-tablets
DES is still sold under different names.

DES was sold under many names including Distilbène®, Stilbetin®, Stilboestrol-Borne®, Benzestrol®, Chlorotrianisene®, Estrobene® and Estrosyn® to name just a few.

Many different companies manufactured and marketed this drug under more than 200 different brand names.

These Apex Stilboestrol tablets are current veterinary products.

DES Drugs Pictures
More DES DiEthylStilbestrol Resources

Stilbestrol Tablets 1mg

Taipei Veterans General Hospital, Taiwan

image of stilbestrol-1mg
Taipei Veterans General Hospital, Taiwan.

DES was sold under many names including Distilbène®, Stilbetin®, Stilboestrol-Borne®, Benzestrol®, Chlorotrianisene®, Estrobene® and Estrosyn® to name just a few.

Many different companies manufactured and marketed this drug under more than 200 different brand names.

These Stilbestrol tablets are current Taipei-VGH drugs marketed by Taipei Veterans General Hospital.

DES Drugs Pictures
More DES DiEthylStilbestrol Resources

Stilbestrol for veterinary use

0.5 mg and 1.0 mg DES tablets manufactured by Ormond Veterinary Supply Inc., Canada

image of stillbestrol
Stilbestrol Tablets manufactured by Ormond Veterinary Supply Inc., Canada.

DES was sold under many names including Distilbène®, Stilbetin®, Stilboestrol-Borne®, Benzestrol®, Chlorotrianisene®, Estrobene® and Estrosyn® to name just a few.

Many different companies manufactured and marketed this drug under more than 200 different brand names.

These Stilbestrol tablets – 0.5 mg and 1.0 mg – are manufactured at Ormond Veterinary Supply Inc. facility, Canada.

DES Drugs Pictures
Related Posts
Related Books
More DES DiEthylStilbestrol Resources

Upper genital tract changes associated with exposure in utero to diethylstilbestrol

American journal of obstetrics and gynecology, 1977

woman-in-the-dark
1977 study : in none of the control subjects were defects noted which could be considered comparable with those seen in the DES-exposed patient.

1977 Study Abstract

Hysterosalpingograms of 60 young women exposed in utero to diethystilbestrol were obtained.

In 46 instances, documentation of this exposure was obtained from the mother’s chart review or confirmed by the attending physician. In 14 instances, the patients’ mothers were sure they had received stilbestrol, but documentation could not be specifically confirmed.

  • In 40 women exposed to stilbestrol, changes in the uterus which differed significantly from those seen in the past in nonexposed individuals were noted. These changes consisted of:
    • a ‘T-shaped appearance of the uterus,
    • ‘ constricting bands in the uterine cavity,
    • a hypoplastic uterus,
    • and less frequently, intrauterine polypoid defects,
    • synechiae,
    • and in one instance a unicornuate uterus.
  • In 36 of the 40 women gross defects were also noted in the cervix.

Hysterosalpingograms of 23 women being investigated for infertility during the same period that the current study was conducted were also reviewed.

  • By comparison, in none of the control subjects were defects noted which could be considered comparable with those seen in the DES-exposed patient.
Sources and more information

Upper genital tract changes associated with exposure in utero to diethylstilbestrol, American journal of obstetrics and gynecology, NCBI PMID: 851159, 1977 May 1.

More DES DiEthylStilbestrol Resources

Wyeth’s Estrogens – American Journal of Obstetrics and Gynecology, 1940s advert

Diethylstilbestrol (DES) was the first synthetic estrogen to be marketed to women

Wyeth's-Estrogens advert image
Diethylstilbestrol (DES), the first synthetic estrogen to be marketed to women.
  • An ad from the American Journal of Obstetrics and Gynecology from 1943.
  • Image sources: Protecting Our Bodies from Hormone-Disrupting Chemicals: A Precautionary Tale, thesolutionsjournal, Feb 2011.
  • Watch our diaporama and DES adverts album on Flickr.
More DES DiEthylStilbestrol Resources

The Newest Knowledge of Nutrition

Wise Burroughs, DES, and Modern Meat

agricultural history book cover image
Alan I. Marcus. Agricultural History, Vol. 67, No. 3 (Summer, 1993), pp. 66-85.

Presents an historical account of animal nutrition research focusing on the 1954 discovery of animal husbandry professor Wise Burroughs of stilbestrol (DES) as a growth-promoting cattle feed additive.

DES feeds’ implications for beef-feeding practices; Burroughs’s research; Ban of DES animal feed due to carcinogenic properties.

By Marcus, Alan I, June 1993.

Sources and book reviews:

  • JSTOR: Agricultural History,
    Vol. 67, No. 3 (Summer, 1993), pp. 66-85.
  • EBSCOhost, 9402020134.
Related posts
Related books
More DES DiEthylStilbestrol Resources

STILBESTROL 25 mg Tablets by DAGRA NV

Diethylstilbestrol or DES was sold under many names

Stilbestrol - Dagra - 25mg
Diethylstilbestrol or DES was sold under many names

Diethylstilbestrol or DES was sold under many names including Distilbène®, Stilbetin®, Stilboestrol-Borne®, Benzestrol®, Chlorotrianisene®, Estrobene® and Estrosyn® to name just a few. Many different companies manufactured and marketed this drug under more than 200 different brand names.

This glass bottle of Stilbestrol tablets was manufactured by Dagra NV
Amsterdam – Antwerpen – London – Madrid

  • Watch the Diaporama, and the DES drugs photo set on flickr®  DES Diethylstilbestrol's photostream on Flickr
  • If you already have a flickr® account, add us as a contact.
    Email your photos to des.daughter@gmail.com with a short description and title :-)
More DES DiEthylStilbestrol Resources