Mécanismes épigénétique des perturbateurs endocriniens

Dr Anne Wautier, Réseau DES France, Forum d’Infertilité 2017

Vidéos en français: Distilbène DES : 60 vidéos à visionner sur YouTube.

Image credit @magicmaman_com.

Le Dr Anne Wautier, gynécologue médicale, aborde de façon très claire (et avec des exemples aidant à la compréhension) des notions complexes telles que : épigénétique, perturbateurs endocriniens, effets transgénérationnels du distilbene DES.

Enregistrement provenant de la 4ème Journée Nationale de l’Infertilité, un forum d’information et d’aide aux personnes infertiles organisé cet automne 2017, Paris 12.

Le Distilbène DES, en savoir plus

Forum d’Infertilité 2017

Avec les Dr Anne Wautier et Pr Michel Tournaire, Réseau DES France

Vidéos en français: Distilbène DES : 60 vidéos à visionner sur YouTube.

Lors de la 4ème Journée Nationale de l’Infertilité, un forum d’information et d’aide aux personnes infertiles organisé cet automne, deux personnalités de l’association Réseau DES France ont partagé leur expertise.

  • le Dr Anne Wautier (45:40) a abordé des notions telles que effets distilbène, épigénétique, perturbateurs endocriniens, effets transgénérationnels.
  • le Pr Michel Tournaire (51:45) a présenté de nouveaux résultats de l’étude Distilbène 3 générations : fertilité et grossesses des “petites-filles DES“.
Le Distilbène DES, en savoir plus

Stupid Cancer App Connects the DES Community Online

Requires iOS 10.0 or later. Compatible with iPhone, iPad, and iPod touch

A new smartphone app from the nonprofit Stupid Cancer gives the DES community a unique opportunity to seek support from others with DES exposure or cancer diagnosis.

The more DES-exposed individuals who use the app, the more valuable it is to everyone in the DES community.

After downloading the free, secure app (initially for Mac only), participants create a profile. By selecting the DES-exposed option in “What was your primary diagnosis?” individuals are instantly matched to others.

Originally shared via Your DES Action Monthly Email Alert!
Join DES Action USA.

More DES DiEthylStilbestrol Resources

Perturbateurs Endocriniens : du Poison pour Nos Enfants

Nos enfants sont- ils condamnés ?

RTBF Auvio, Questions à la une, 16.11.2017.

Ecoutez Tifenn, de l’association Réseau DES France, nous parler de la 3ème génération de victimes exposées au médicament distilbène, modèle de perturbateurs endocriniens.

Avec l’avènement de la chimie, les perturbateurs endocriniens ont envahi notre environnement. Ils sont partout : dans le plastique de nos cuisines, au coeur de nos ordinateurs, dans le moteur et la peinture de nos voitures, dans nos assiettes, et même dans l’air que nous respirons. Impossible d’y échapper !

Mais ces substances parasitent notre système hormonal et dérèglent notre organisme. Les scientifiques tirent la sonette d’alarme. Infertilité, obésité, trouble de l’attention, perte de mémoire et même cancer… Les pathologies qu’on attribue aux perturbateurs endocriniens explosent.

Le Distilbène DES, en savoir plus

MPs Challenge the EWG Report Findings in ref to Primodos and Hormone Pregnancy Tests

MPs attack “whitewash” report on hormone pregnancy test drugs

MP Justin Madders has written to govt asking why the Primodos expert working group changed the conclusion of its controversial report.

A large number of MPs have challenged the findings of the EWG report, a government-led review which suggested the Primodos pregnancy test drug was not responsible for causing deformities to children.

I know the Minister very well. He is a passionate and caring Minister, but I am afraid that I disagree with many of the things he said this morning. The families do—I think, rightly—feel that the report is a whitewash. Material has been removed from the draft, and the group looked into matters that were not within its remit. The question of a causal link was not in its remit. The question was whether there was link with a drug that was often given to our constituents with no prescription: a drawer would be opened, and it would be handed out to them so that they could find out whether they were pregnant. An open inquiry was needed, but I am afraid that the families, and many Members who are present today, will not feel that that was what happened. Will the Minister please meet the families again, with members of the all-party group, and try to understand why they are so upset? Will the Minister please also watch last night’s report on Sky News, which exposes much of what has being going on over many Parliaments? No matter who was in government, Governments have ignored these people, and we cannot continue to do so.

Mike Penning,
Conservative, Hemel Hempstead

On Friday, two constituents came to my surgery to speak to me about exactly this. The mother had taken one of these pills and her daughter was born with deformities. This is not the Minister’s report—he is just giving his explanation and doing his job—but may I suggest that we have a proper Back-Bench debate in which we can exercise all these issues? With great respect to the working group, and having had some experience as a former public health Minister and knowing about contaminated blood, I am afraid to say that I smell something like a very large rat in all of this. I think that there have been cover-ups.

Anna Soubry,
Conservative, Broxtowe

My hon. Friend is clearly struggling to defend this position. I urge him to look at the scope of this review and all the evidence that was presented to it, as all the evidence that was available should be looked at and looked at again. Without that, many people across this country will not be satisfied that justice has been done.

Bob Blackman,
Conservative, Harrow East

It is my understanding that in the research on fish, the researcher was reluctant to submit the findings because they had not been peer-reviewed. Is the Minister confident that all the animal studies that were considered in this review were properly and adequately peer-reviewed? We now know there are many studies included that were not peer reviewed.

Liz McInnes,
Shadow Minister (Foreign and Commonwealth Affairs)

Like Anna Soubry, I am reminded of the contaminated blood inquiry, which is ongoing. In 1975, the regulator knew that there was a potential 5:1 risk of the drug causing deformity. They told the manufacturers but not the patients, and papers were deliberately destroyed by the chief scientist. It is deeply worrying to the families that there is not an open and transparent investigation into this matter. Does the Minister know whether the Berlin archive papers were examined as part of this inquiry, because they demonstrate the cover-up that has happened over many years?

Madeleine Moon,
Chair, Defence Sub-Committee

I come to this having had no constituency involvement in this issue at all, but I have been listening to the exchanges this morning and it is quite clear that the level of concern on both sides of the House is sufficient for the Government to call a debate on the matter in Government time, so that all these issues can be properly explored.

Philip Hollobone,
Conservative, Kettering

Is the Minister aware of the study in 1979 from Primodos that concluded that the visceral malformations should be considered to be drug-related? The manufacturer seems to have made a link that does not appear to have been dealt with in the report. Does he acknowledge that serious concern is being expressed on both sides of the House about the transparency of this report and that it behoves us all to try to make it transparent and understandable and, above all, to get to the correct answer?

Martin Whitfield,
Labour, East Lothian

The report must be judged against the background of the fact that the thalidomide scandal involved only 20 birth defects in America and 2,000 in this country, that we are still misinforming and under-informing mothers and potential mothers about the valproate scandal and that GlaxoSmithKline was fined $3 billion for distorting the results of its research. The Minister must tell us how many members of the expert group are present or past employees of the pharmaceutical industry.

Paul Flynn,
Labour, Newport West

I have a constituent who has been affected by this issue, and they want justice. Based on what I have heard today, justice has fallen short in this case. In any normal circumstances, justice must not only be done, but it must be seen to be done. If the criteria have not been applied correctly, we would in normal circumstances have a review to get the correct decision in the end. Will the Minister look at the matter and get it reviewed?

Rehman Chishti,
Conservative, Gillingham and Rainham

Is the Minister aware that in all the years that I have been here, I have never heard of such a decision, particularly one made by this party, presented by a Minister of Health who is constantly telling us all about the Stafford inquiry and how important the last Stafford inquiry was? It is time that he considered the possibility of having this thing reviewed, bearing in mind that we are dealing with drug firms that have millions and millions of pounds. He should start all over again from the beginning. It will otherwise be a bad day for the Government if he is allowed to say what he has without listening to the people from both sides of the House who have rubbished the report.

Dennis Skinner,
Labour, Bolsover

As has been said, this is absolutely not a party matter. Colleagues have expressed their interest in a debate on this matter, and I can simply say from the Chair that, one way or the other, through one vehicle or another, this matter will be debated if Members want it to be debated.

John Bercow,
Speaker of the House of Commons, Chair, Speaker’s Committee on the Electoral Commission, Chair, Speaker’s Committee for the Independent Parliamentary Standards Authority, Chair, Commons Reference Group on Representation and Inclusion Committee

House of Commons

Urgent Question: Hormone pregnancy tests,
Thursday 16 November 2017, check from 10:40 to 11:11 here.

UK Commission on Human Medicines

  • Report of the Commission on Human Medicines’ Expert Working Group on Hormone Pregnancy Tests, gov.uk.
  • Referral letter for genetic testing, gov.uk.
  • Press coverage, news.google.

More About Primodos

Causal Association Between Primodos and Birth Defects : the EWG report

Report of the Commission on Human Medicines’ Expert Working Group on Hormone Pregnancy Tests

An Expert Working Group (EWG) of the UK’s Commission on Human Medicines (CHM) has published their report on the use of hormone pregnancy tests (HPTs) and adverse effects relating to pregnancy including possible birth defects.

Sky’s Jason Farrell confirms alleged victims of pregnancy test Primodos slam EWG report which found the drug was not responsible for serious birth defects. Campaigners say that the hormone pregnancy test review was a complete whitewash.

Commission on Human Medicines

  • Report of the Commission on Human Medicines’ Expert Working Group on Hormone Pregnancy Tests, gov.uk.
  • Referral letter for genetic testing, gov.uk.
  • Press coverage, news.google.

More About Primodos

Primodos EWG Report : Jason Farrell Reveals

Report of the Commission on Human Medicines’ Expert Working Group on Hormone Pregnancy Tests

An Expert Working Group (EWG) of the UK’s Commission on Human Medicines (CHM) has published their report on the use of hormone pregnancy tests (HPTs) and adverse effects relating to pregnancy including possible birth defects.

Sky’s Jason Farrell shares some thoughts.

Commission on Human Medicines

  • Report of the Commission on Human Medicines’ Expert Working Group on Hormone Pregnancy Tests, gov.uk.
  • Referral letter for genetic testing, gov.uk.
  • Press coverage, news.google.

More About Primodos

La face cachée du lait

En quête d’actualité, Culture Infos, 2015

La pression économique et la logique industrielle ont rendu les méthodes de production – et de tarification – du lait pas toujours très transparentes.

Le magazine a enquêté pour découvrir, entre autres, les raisons qui expliquent les importants écarts de prix entre les différentes marques, le fonctionnement des exploitations géantes ainsi que les conséquences de leurs méthodes de fabrication pour la santé • Bio : peut-on toujours avoir confiance ? La grande distribution propose aujourd’hui ces produits à prix cassé, mettant le 100 % naturel à la portée de tous. Mais comment est-il possible d’être jusqu’à deux fois moins cher que les magasins spécialisés ? Plongée dans les coulisses du bio low cost pour voir s’il tient vraiment ses promesses.

Diffusé le 20 mars 2015, En quête d’actualité.

Le lait : mensonges et vérités

Les produits laitiers sont-ils nos amis pour la vie ? Vérité, mensonges et propagande

On a longtemps affirmé que le lait était bon pour la santé. Or, aujourd’hui, ses vertus sont de plus en plus remises en cause. Quelle est la différence entre le lait cru et celui que nous trouvons dans le commerce ? Les produits sans lactose ne présentent-ils que des avantages pour les consommateurs ? Le lait bio est-il réellement meilleur pour la santé ? « Xenius » mène l’enquête.

Le lait, ami ou poison ? Indispensables à une alimentation équilibrée et source de nombreux nutriments pour les uns, associés au développement de maladies pour les autres, les produits laitiers suscitent aujourd’hui une vive controverse. Enquête sur le lait et ses dérivés, sujet qui déchaîne aujourd’hui les passions.

Diffusé le 10/01/2017, arte.

Industrie agro-alimentaire : business contre santé

Les magazines de France 2, Cash Investigation, Présenté par Elise Lucet, 2016

Un film de Sandrine Rigaud avec Guillaume Coudray.

Pourquoi le jambon est-il rose ? Pourquoi a-t-il la réputation d’être bon pour les enfants ? Elise Lucet révèle les recettes inavouables des géants de l’agroalimentaire. De la Bretagne au Danemark en passant par la Californie et le Wisconsin, pendant un an, une équipe a avalé les kilomètres, en avion, en voiture et en caddy pour déterminer comment ces mastodontes de l’assiette pèsent sur les décisions de santé publique, à leur avantage. Elise Lucet prolonge l’enquête avec des experts et des responsables politiques.

Diffusé le 13/09/2016, franceinfo.