Urogenital tract abnormalities in sons of women treated with diethylstilbestrol

1976 Study Abstract

Since in utero exposure to Diethylstilbestrol (DES) is known to cause abnormalities of the female genital tract later in life, exposed male offspring were located, surveyed by mail, and compared with unexposed male offspring from the same period and medical practices.

The exposed and unexposed respondents appeared comparable and did not differ in their response to most medical questions. However, a larger proportion of exposed than of unexposed boys had experienced problems in passing urine (12.9% vs. 1.8%, P = .0003) and abnormalities of the penile urethra (4.4% vs. 0%; P = .017).

Sources and more information

• Urogenital tract abnormalities in sons of women treated with diethylstilbestrol, Pediatrics. NCBI PMID: 972792, 1976 Oct;58(4):505-7.
• Urogenital abnormalities in men exposed to diethylstilbestrol in utero: a cohort study, NCBI, PMID: 19689815, 2009 Aug 18;8:37. doi: 10.1186/1476-069X-8-37. Full text PMC2739506.

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