HPV associated with vaginal intraepithelial neoplasia in women exposed to DES in utero

Close follow-up is recommended for DES-exposed patients, especially those who have risk factors known to be associated with genital neoplasia

image of hpv virus
The role of human papillomavirus and herpes simplex virus in the etiology of intraepithelial neoplasia is discussed in this 1987 study.

Study Abstract

Human papillomavirus associated with vaginal intraepithelial neoplasia in women exposed to diethylstilbestrol in utero, Obstetrics and gynecology, NCBI PubMed PMID: 3037458,
1987 Jul.

Five out of 959 young women, exposed to diethylstilbestrol (DES) in utero, developed vaginal intraepithelial neoplasia while they were under follow-up in the Diethylstilbestrol-Adenosis Project at Baylor College of Medicine, Houston, Texas.

We suggest that the development of the vaginal intraepithelial neoplasia at a younger age than usual may be caused by a higher susceptibility of the DES-exposed patient to factors associated with the development of intraepithelial neoplasia. A common finding in all five women was the detection of the deoxyribonucleic acid (DNA) of human papillomavirus types 6 or 16 in their lesions, using high-stringency in situ hybridization.

The role of human papillomavirus and herpes simplex virus in the etiology of intraepithelial neoplasia is discussed.

Close follow-up is recommended for DES-exposed patients, especially those who have risk factors known to be associated with genital neoplasia.

More DES DiEthylStilbestrol Resources

In-Utero DES Exposure associated with a Higher Rate of Herpes and HPV infections

Development of cervical and vaginal squamous cell neoplasia as a late consequence of in utero exposure to diethylstilbestrol

herpes-simplex-virus
In 1984, the DES-Adenosis (DESAD) Project found that DES-exposed daughters are associated with a higher rate of herpes simplex virus and human papillomavirus infections.

1988 Study Abstract

During the last 14 years, several articles have given contradictory reports on prevalence rates of squamous cell neoplasia of the cervix and vagina in diethylstilbestrol (DES)-exposed progeny.

In 1984, the DES-Adenosis (DESAD) Project found that the incidence of cervical and vaginal intraepithelial neoplasia in DES-exposed daughters was twice as high as in a comparison group of unexposed women.

This was also associated with a higher rate of herpes simplex virus and human papillomavirus infections. Possible hypotheses on the etiology of the increased incidence of squamous neoplasia are discussed.

Sources and more information
  • Development of cervical and vaginal squamous cell neoplasia as a late consequence of in utero exposure to diethylstilbestrol,
    NCBI PMID: 2829071, Obstet Gynecol Surv. 1988 Jan;43(1):15-21.
More DES DiEthylStilbestrol Resources