Exposure to Glyphosate-Based Herbicides and Risk for Non-Hodgkin Lymphoma

A Meta-Analysis and Supporting Evidence, Mutation Research/Reviews, February 2019

Abstract

Glyphosate is the most widely used broad-spectrum systemic herbicide in the world. Recent evaluations of the carcinogenic potential of glyphosate-based herbicides (GBHs) by various regional, national, and international agencies have engendered controversy.

We investigated whether there was an association between high cumulative exposures to GBHs and increased risk of non-Hodgkin lymphoma (NHL) in humans. We conducted a new meta-analysis that included the most recent update of the Agricultural Health Study (AHS) cohort published in 2018 along with five case-control studies.

Using the highest exposure groups when available in each study, we report the overall meta-relative risk (meta-RR) of NHL in GBH-exposed individuals was increased by 41% (meta-RR = 1.41, 95% CI, confidence interval: 1.13–1.75). For comparison, we also performed a secondary meta-analysis using high-exposure groups with the earlier AHS (2005), and we determined a meta-RR for NHL of 1.45 (95% CI: 1.11–1.91), which was higher than the meta-RRs reported previously. Multiple sensitivity tests conducted to assess the validity of our findings did not reveal meaningful differences from our primary estimated meta-RR. To contextualize our findings of an increased NHL risk in individuals with high GBH exposure, we reviewed available animal and mechanistic studies, which provided supporting evidence for the carcinogenic potential of GBH. We documented further support from studies of malignant lymphoma incidence in mice treated with pure glyphosate, as well as potential links between GBH exposure and immunosuppression, endocrine disruption, and genetic alterations that are commonly associated with NHL.

Overall, in accordance with evidence from experimental animal and mechanistic studies, our current meta-analysis of human epidemiological studies suggests a compelling link between exposures to GBHs and increased risk for NHL.

 

Reference. Image credit gmwatch.

Worldwide decline of the entomofauna : a review of its drivers

Over 40 percent of insect species face extinction : study

New research suggests more than 40 percent of insect species “are threatened with extinction.

2019 Study Highlights

  • Over 40% of insect species are threatened with extinction.
  • Lepidoptera, Hymenoptera and dung beetles (Coleoptera) are the taxa most affected.
  • Four aquatic taxa are imperiled and have already lost a large proportion of species.
  • Habitat loss by conversion to intensive agriculture is the main driver of the declines.
  • Agro-chemical pollutants, invasive species and climate change are additional causes.

Abstract

Biodiversity of insects is threatened worldwide. Here, we present a comprehensive review of 73 historical reports of insect declines from across the globe, and systematically assess the underlying drivers. Our work reveals dramatic rates of decline that may lead to the extinction of 40% of the world’s insect species over the next few decades. In terrestrial ecosystems, Lepidoptera, Hymenoptera and dung beetles (Coleoptera) appear to be the taxa most affected, whereas four major aquatic taxa (Odonata, Plecoptera, Trichoptera and Ephemeroptera) have already lost a considerable proportion of species. Affected insect groups not only include specialists that occupy particular ecological niches, but also many common and generalist species. Concurrently, the abundance of a small number of species is increasing; these are all adaptable, generalist species that are occupying the vacant niches left by the ones declining. Among aquatic insects, habitat and dietary generalists, and pollutant-tolerant species are replacing the large biodiversity losses experienced in waters within agricultural and urban settings.

The main drivers of species declines appear to be in order of importance:

  1. habitat loss and conversion to intensive agriculture and urbanisation;
  2. pollution, mainly that by synthetic pesticides and fertilisers;
  3. biological factors, including pathogens and introduced species;
  4. and climate change. The latter factor is particularly important in tropical regions, but only affects a minority of species in colder climes and mountain settings of temperate zones.

A rethinking of current agricultural practices, in particular a serious reduction in pesticide usage and its substitution with more sustainable, ecologically-based practices, is urgently needed to slow or reverse current trends, allow the recovery of declining insect populations and safeguard the vital ecosystem services they provide. In addition, effective remediation technologies should be applied to clean polluted waters in both agricultural and urban environments.

Reference.

La désinformation organisée par les firmes doit cesser, dit Maître Lafforgue

Comment Monsanto assure sa défense et nie en bloc toute responsabilité devant la justice

“Les médecins qui mettent en doute les troubles de M. François ne sont pas des experts judiciaires, ce sont des consultants payés par Monsanto.”

dénonce Maître François Lafforgue, l’avocat de Paul François.

La Cour d’appel de Lyon doit se prononcer sur la responsabilité présumée de Monsanto dans les troubles médicaux de Paul François, céréalier charentais. Depuis douze ans, il accuse la firme d’avoir exposé les utilisateurs du Lasso, puissant herbicide, à de graves dangers.

France 3 Auvergne-Rhône-Alpes, un reportage de Yaëlle Marie et Laure Crozat publié sur YouTube le 6 février 2019.

Référence : Lyon : Comment Monsanto assure sa défense et nie en bloc toute responsabilité devant la justice ?

Glyphosate : comment s’en sortir ?

Grande soirée événementielle d'”Envoyé spécial” – 17 janvier 2019

Peut-on sortir du glyphosate ? Pourquoi est-il aussi long et difficile d’interdire cet herbicide, considéré par de nombreux scientifiques comme dangereux pour la santé ?

Sommaire:

Envoyé spécial, un reportage exceptionnel présenté par Elise Lucet, publié sur YouTube le 21 janvier 2019.

Référence : “Envoyé spécial”. Glyphosate : comment s’en sortir ?.

Sri Lanka, un pays sans glyphosate

Le gouvernement a décidé en 2015 d’interdire le glyphosate, une mesure radicale unique au monde

Comment, dans les campagnes, les rizières, les plantations, a-t-on appris à vivre sans glyphosate ?

Le glyphosate, l’herbicide le plus vendu au monde, a fait couler beaucoup d’encre en 2017 et 2018.

Envoyé spécial, un reportage d’Elise Menand, Swanny Thiébaut, Cédric Baume et Marielle Krouk, publié sur YouTube le 23 janvier 2019.

Référence : “Envoyé spécial”. Glyphosate : comment s’en sortir ?.

Comment les députés n’ont pas pu voter l’inscription dans la loi de l’interdiction du glyphosate

.Le vote impossible. Un hémicycle presque vide

Envoyé spécial” décrypte les coulisses de cette soirée du 28 mai 2018 à l’Assemblée nationale. Et a demandé aux 577 députés pourquoi la plupart d’entre eux n’ont pas pris part au vote.

Le glyphosate, l’herbicide le plus vendu au monde, a fait couler beaucoup d’encre en 2017 et 2018.

Envoyé spécial, un reportage de Laura Aguirre de Carcer, Tristan Waleckx, Olivier Gardette, Marielle Krouk et Karim Annette publié sur YouTube le 22 janvier 2019.

Référence : “Envoyé spécial”. Glyphosate : comment s’en sortir ?.

(Bayer), Monsanto, et la fabrique du doute

Une firme, qui ne s’estime ni responsable ni coupable, et fait appel de ses condamnations ?

Les “Monsanto Papers” ont révélé comment le géant américain a fait rédiger en secret, par ses propres scientifiques, des études pour prouver que le glyphosate n’était pas dangereux.

Le glyphosate, l’herbicide le plus vendu au monde, a fait couler beaucoup d’encre en 2017 et 2018.

Envoyé spécial, un reportage de Tristan Waleckx, Guillaume Beaufils et Mikael Bozo publié sur YouTube le 22 janvier 2019.

Référence : “Envoyé spécial”. Glyphosate : comment s’en sortir ?.

Glypho or not glypho ?

Les agriculteurs concernés au premier chef

Vincent et Olivier sont tous les deux céréaliers, l’un est pro-glyphosate, l’autre 100% bio. Chacun va passer quelques jours dans l’exploitation de l’autre.

Le glyphosate, l’herbicide le plus vendu au monde, a fait couler beaucoup d’encre en 2017 et 2018.

Envoyé spécial, un reportage de Laura Aguirre de Carcer, Olivier Gardette, Marielle Krouk, publié sur YouTube le 21 janvier 2019.

Référence : “Envoyé spécial”. Glyphosate : comment s’en sortir ?.

Un monde sans pesticides

Quelles alternatives pour une agriculture sans pesticides ?

  • France Culture, De cause à effets, le magazine de l’environnement par Aurélie Luneau.
  • Avec François Veillerette, Ecologiste miltant, Marie-Hélène Jeuffroy, Directrice de Recherches à l’INRA et Jean-Bernard Lozier, Agriculteur.

Références : LeMonde et iTunes, 27/01/2019.

The negative impact of the environment on methylation/epigenetic marking in gametes and embryos

A plea for action to protect the fertility of future generations, 17 January 2019

Abstract

Life expectancy has increased since World War II and this may be attributed to several aspects of modern lifestyles. However, now we are faced with a downturn, which seems to be the result of environmental issues. This paradigm is paralleled with a reduction in human fertility: decreased sperm quality and increased premature ovarian failure and diminished ovarian reserve syndromes.

Endocrine Disruptor Compounds (EDCs) and other toxic chemicals: herbicides, pesticides, plasticizers, to mention a few, are a rising concern in today environment. Some of these are commonly used in the domestic setting: cleaning material and cosmetics and they have a known impact on epigenesis and imprinting via perturbation of methylation processes. Pollution from Poly Aromatic Hydrocarbons (PAH), particulate matter (PM), <10 and <2.5 μm and ozone, released into the air all affect fertility. Poor food processing management is a source DNA adducts formation, impairing gametes quality. An important question to be answered is that of nanoparticles (NPs) that are present in food and which are thought to induce oxidative stress. Now is the time to take a step backwards. Global management of the environment and food production is required urgently in order to protect the fertility of future generations.

Reference.

DES and the GENES